Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival
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DOI: 10.1038/ncb3518
Abstract: The IRE1–XBP1 signalling pathway is part of a cellular programme that protects against endoplasmic reticulum (ER) stress, but also controls development and survival of immune cells. Loss of XBP1 in splenic type 1 conventional dendritic… read more here.
Keywords: cell survival; regulated ire1; ire1 dependent; cell ... See more keywords
Palmitate inhibits arthritis by inducing t-bet and gata-3 mRNA degradation in iNKT cells via IRE1α-dependent decay
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14780-4
Abstract: Long chain fatty acids (LCFAs) exert pro-inflammatory effects in vivo. However, little is known regarding the effect of LCFAs on invariant (i) NKT cell functions. Here, we report an inhibitory effect of saturated LCFAs on… read more here.
Keywords: gata bet; degradation; inkt; ire1 dependent ... See more keywords