Impairment of both IRE1 expression and XBP1 activation is a hallmark of GCB DLBCL and contributes to tumor growth.
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DOI: 10.1182/blood-2016-09-741348
Abstract: The endoplasmic reticulum kinase inositol-requiring enzyme 1 (IRE1) and its downstream target X-box-binding protein 1 (XBP1) drive B-cell differentiation toward plasma cells and have been shown to contribute to multiple myeloma development; yet, little is… read more here.
Keywords: dlbcl; ire1 expression; gcb dlbcl; tumor growth ... See more keywords