Design, Synthesis, and Cellular Efficacy of Inositol-Requiring Enzyme Type 1 (IRE1α) Inhibitors.
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DOI: 10.1021/acsmedchemlett.5c00418
Abstract: A library of 66 small molecules targeting IRE1α were designed using a molecular docking approach and prepared by a two-step reaction sequence using diverse substrates. All compounds utilized a 1-amino-4-bromonaphthalene core that was modified via… read more here.
Keywords: ire1 inhibitors; ire1 inhibition; ire1; design synthesis ... See more keywords
P01.12.B COMBINED EFFECTS OF IRE1 INHIBITION AND TEMOZOLOMIDE IN GLIOBLASTOMA MOUSE MODELS: POTENTIAL MECHANISMS OF ACTION
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf193.092
Abstract: Glioblastoma (GB), the most frequent and aggressive primary brain tumor in adult, remains an incurable disease. New efficient therapy is required to improve patient care. We showed that coupling temozolomide (TMZ) treatment with a pharmacological… read more here.
Keywords: treatment; tmz; inhibition; ire1 inhibition ... See more keywords