Binding Analysis of the Inositol-Requiring Enzyme 1 Kinase Domain
Sign Up to like & getrecommendations! Published in 2018 at "ACS Omega"
DOI: 10.1021/acsomega.8b01404
Abstract: Inositol-requiring enzyme 1 (IRE1) is an orchestrator of the unfolded protein response (UPR), the cellular response to endoplasmic reticulum (ER) stress that plays a crucial role in tumor development. IRE1 signaling is the most evolutionary… read more here.
Keywords: inositol requiring; kinase; kinase domain; ire1 kinase ... See more keywords
Disruption of IRE1α through its kinase domain attenuates multiple myeloma
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1906999116
Abstract: Significance Multiple myeloma (MM) is a lethal malignancy arising from plasma cells. MM cells experience endoplasmic reticulum (ER) stress due to immunoglobulin hyperproduction. The ER-resident sensor IRE1α mitigates ER stress by expanding protein-folding and secretion… read more here.
Keywords: xbp1s; kinase; multiple myeloma; ire1 kinase ... See more keywords