Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes.
Sign Up to like & getrecommendations! Published in 2017 at "Cell metabolism"
DOI: 10.1016/j.cmet.2017.03.018
Abstract: In cells experiencing unrelieved endoplasmic reticulum (ER) stress, the ER transmembrane kinase/endoribonuclease (RNase)-IRE1α-endonucleolytically degrades ER-localized mRNAs to promote apoptosis. Here we find that the ABL family of tyrosine kinases rheostatically enhances IRE1α's enzymatic activities, thereby… read more here.
Keywords: ire1 rnase; abl ire1; targeting abl; ire1 signaling ... See more keywords
Dihydromyricetin alleviates endothelial inflammatory response through IRE1α/NF-κB signaling pathway in sepsis
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Medical Science"
DOI: 10.5114/aoms/132293
Abstract: Introduction The high mortality of sepsis is closely related to disorder of coagulation induced by endothelial inflammatory response. Our aim is to investigate the protective effects of Dihydromyricetin (DHM) on endothelial cells in sepsis and… read more here.
Keywords: sepsis; inflammatory response; signaling pathway; ire1 signaling ... See more keywords