Bip-Yorkie interaction determines oncogenic and tumor-suppressive roles of Ire1/Xbp1s activation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2202133119
Abstract: Significance Unfolded protein response (UPR) is thought to coordinate cell growth and proliferation by governing endoplasmic reticulum (ER) proteostasis; however, the mechanisms underlying this fundamental adaptation process remain poorly defined. Here, by using Drosophila, mammalian… read more here.
Keywords: yorkie interaction; ire1 xbp1s; bip yorkie; bip ... See more keywords
Ligustilide Improves Cognitive Impairment via Regulating the SIRT1/IRE1α/XBP1s/CHOP Pathway in Vascular Dementia Rats
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/6664990
Abstract: Vascular dementia (VaD), the second cause of dementia, is caused by chronic cerebral hypoperfusion, producing progressive damage to cerebral cortex, hippocampus, and white matter. Ligustilide (LIG), one of the main active ingredients of Angelica sinensis,… read more here.
Keywords: vad rats; ire1 xbp1s; chop; vad ... See more keywords
The IRE1-XBP1s Pathway Impairment Underpins NK Cell Dysfunction in Hodgkin Lymphoma, That Is Partly Restored By PD-1 Blockade
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-126372
Abstract: Background The frequent loss of Major Histocompatibility Complex I molecule (MHC-I) on Hodgkin/Reed-Sternberg (HRS)-cells renders them susceptible to Natural Killer (NK) cell-mediated lysis in Hodgkin Lymphoma (HL). Optimal NK cell function involves migration from peripheral… read more here.
Keywords: function; cell; ire1 xbp1s; xbp1s pathway ... See more keywords