A boron-based Ireland-Claisen approach to the synthesis of pordamacrine A
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DOI: 10.1016/j.tet.2016.11.030
Abstract: Abstract A synthetic approach to pordamacrine A that features two key transformations is discussed. The first transformation applies an Ireland-Claisen rearrangement to establish sterically congested vicinal carbon centers. Although a hard enolization technique for accessing… read more here.
Keywords: based ireland; ireland claisen; pordamacrine; approach ... See more keywords
Global Diastereoconvergence in the Ireland-Claisen Rearrangement of Isomeric Enolates: Synthesis of Tetrasubstituted α-Amino Acids.
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DOI: 10.1021/jacs.0c11480
Abstract: A dual experimental/theoretical investigation of the Ireland-Claisen rearrangement of tetrasubstituted α-phthalimido ester enolates to afford α-tetrasubstituted, β-trisubstituted α-amino acids (generally >20:1 dr) is described. For trans allylic olefins, the Z- and E-enol ethers proceed through… read more here.
Keywords: claisen rearrangement; amino acids; ireland claisen; global diastereoconvergence ... See more keywords