Sequence features of viral and human Internal Ribosome Entry Sites predictive of their activity
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DOI: 10.1371/journal.pcbi.1005734
Abstract: Translation of mRNAs through Internal Ribosome Entry Sites (IRESs) has emerged as a prominent mechanism of cellular and viral initiation. It supports cap-independent translation of select cellular genes under normal conditions, and in conditions when… read more here.
Keywords: ribosome entry; ires activity; internal ribosome; activity ... See more keywords
Polypyrimidine-Tract-Binding Protein Isoforms Differentially Regulate the Hepatitis C Virus Internal Ribosome Entry Site
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DOI: 10.3390/v15010008
Abstract: Translation initiation of the hepatitis C virus (HCV) mRNA depends on an internal ribosome entry site (IRES) that encompasses most of the 5′UTR and includes nucleotides of the core coding region. This study shows that… read more here.
Keywords: ptb1 ptb4; binding protein; ires activity; hcv ires ... See more keywords
Hyperglycemia facilitates EV71 replication: Insights into miR-206-mediated regulation of G3BP2 promoting EV71 IRES activity
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DOI: 10.7150/thno.93883
Abstract: Background: Neurotropic virus infections actively manipulate host cell metabolism to enhance virus neurovirulence. Although hyperglycemia is common during severe infections, its specific role remains unclear. This study investigates the impact of hyperglycemia on the neurovirulence… read more here.
Keywords: replication; ires activity; virus; hyperglycemia ... See more keywords