EIF4G2 Promotes Hepatocellular Carcinoma Progression via IRES-dependent PLEKHA1 Translation Regulation.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.4c00457
Abstract: Hepatocellular carcinoma (HCC) is a highly lethal cancer, and proteomic studies have shown increased protein diversity and abundance in HCC tissues, whereas the role of protein translation has not been extensively explored in HCC. Our… read more here.
Keywords: ires dependent; hcc; hepatocellular carcinoma; translation ... See more keywords
DKC1-mediated pseudouridylation of rRNA targets hnRNP A1 to sustain IRES-dependent translation and ATF4-driven metabolic adaptation
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.adv9401
Abstract: The pseudouridine synthase DKC1 regulates internal ribosome entry site (IRES)–dependent translation and is up-regulated in cancers by the MYC family of oncogenes. The functional significance of DKC1 up-regulation and the mechanistic connection between pseudouridylation and… read more here.
Keywords: ires dependent; dependent translation; pseudouridylation; dkc1 ... See more keywords
DDX21, a Host Restriction Factor of FMDV IRES-Dependent Translation and Replication
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13091765
Abstract: In cells, the contributions of DEAD-box helicases (DDXs), without which cellular life is impossible, are of utmost importance. The extremely diverse roles of the nucleolar helicase DDX21, ranging from fundamental cellular processes such as cell… read more here.
Keywords: ires dependent; fmdv ires; dependent translation; ddx21 ... See more keywords