Dynamics of IRES-mediated translation
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DOI: 10.1098/rstb.2016.0177
Abstract: Viral internal ribosome entry sites (IRESs) are unique RNA elements, which use stable and dynamic RNA structures to recruit ribosomes and drive protein synthesis. IRESs overcome the high complexity of the canonical eukaryotic translation initiation… read more here.
Keywords: ires mediated; iress; initiation; translation ... See more keywords
Drug Screening for Hepatitis A Virus (HAV): Nicotinamide Inhibits c-Jun Expression and HAV Replication
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DOI: 10.1128/jvi.01987-22
Abstract: Drug screening methods targeting HAV IRES-mediated translation with reporter assays are attractive and useful for drug repurposing. Nicotinamide (vitamin B3, niacin) has been shown to effectively inhibit HAV replication. ABSTRACT Hepatitis A virus (HAV) infection… read more here.
Keywords: mediated translation; ires mediated; replication; hav replication ... See more keywords
Internal Ribosome Entry Site (IRES)-Mediated Translation and Its Potential for Novel mRNA-Based Therapy Development
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DOI: 10.3390/biomedicines10081865
Abstract: Many conditions can benefit from RNA-based therapies, namely, those targeting internal ribosome entry sites (IRESs) and their regulatory proteins, the IRES trans-acting factors (ITAFs). IRES-mediated translation is an alternative mechanism of translation initiation, known for… read more here.
Keywords: mediated translation; ires mediated; ribosome entry; development ... See more keywords
Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics
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DOI: 10.3390/ijms18010093
Abstract: While translational regulation of p53 by the internal ribosome entry site (IRES) at its 5′-untranslated region following DNA damage has been widely accepted, the detailed mechanism underlying the translational control of p53 by its IRES… read more here.
Keywords: ires mediated; mediated p53; diagnosis therapeutics; cancer diagnosis ... See more keywords