Identification of STXBP6-IRF1 positive feedback loop in regulation of PD-L1 in cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02678-6
Abstract: The clinical success of immune checkpoint blockade against diverse human cancers highlights the critical importance of insightful understanding into mechanisms underlying PD-L1 regulation. IFN-γ released by intratumoral lymphocytes regulates PD-L1 expression in tumor cells through… read more here.
Keywords: positive feedback; feedback loop; cancer; irf1 ... See more keywords
Nur77-IRF1 axis inhibits esophageal squamous cell carcinoma growth and improves anti-PD-1 treatment efficacy
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death Discovery"
DOI: 10.1038/s41420-024-02019-x
Abstract: The nuclear receptor Nur77 plays paradoxical roles in numerous cancers. However, whether Nur77 inhibits esophageal squamous cell carcinoma (ESCC) growth and affects immunological responses against ESCC has not been determined. The functional role of Nur77… read more here.
Keywords: irf1; nur77; efficacy; cell ... See more keywords
GSK3β-SCFFBXW7α mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz163
Abstract: Abstract IRF1 (Interferon Regulatory Factor-1) is the prototype of the IRF family of DNA binding transcription factors. IRF1 protein expression is regulated by transient up-regulation in response to external stimuli followed by rapid degradation via… read more here.
Keywords: transcription; scffbxw7 mediated; turnover; gsk3 scffbxw7 ... See more keywords
XAF1 Protects Host against Emerging RNA Viruses by Stabilizing IRF1-Dependent Antiviral Immunity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00774-22
Abstract: Rapid and robust induction of antiviral genes is essential for the host to clear the invaded viruses. In addition to the IRF3/7-IFN-I-STAT1 signaling axis, the XAF1-IRF1 positive feedback loop synergistically or independently drives the transcription… read more here.
Keywords: irf1; host; antiviral immunity; xaf1 ... See more keywords
Interferon regulatory factor 1 (IRF1) controls the metabolic programmes of low-grade pancreatic cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Gut"
DOI: 10.1136/gutjnl-2021-325811
Abstract: Objective Pancreatic ductal adenocarcinomas (PDACs) include heterogeneous mixtures of low-grade cells forming pseudoglandular structures and compact nests of high-grade cells organised in non-glandular patterns. We previously reported that low-grade PDAC cells display high expression of… read more here.
Keywords: grade; expression; pdac cells; irf1 ... See more keywords
Abstract Tu0028: Regulation of Atherosclerotic Cardiovascular Disease by Long Noncoding RNA IRF1-AS1
Sign Up to like & getrecommendations! Published in 2025 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atv.45.suppl_1.tu0028
Abstract: A major cause of cardiovascular disease is atherosclerosis, a condition in which imbalances in lipid metabolism and maladaptive immune responses drive chronic inflammation in the artery wall resulting in plaque formation. Investigating the molecular mechanisms… read more here.
Keywords: irf1 as1; regulation; cardiovascular disease; irf1 ... See more keywords
Erastin Induces Ferrotposis in Multiple Myeloma Cells through SLC7A11-IRF1-Txn Axis
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-209081
Abstract: Introduction:Multiple myeloma (MM) is the second most common hematological malignancy characterized by genetic heterogeneity. Ferroptosis is a newly defined form of regulated cell death with promising antitumor results in some cancers, while the relationship between… read more here.
Keywords: irf1; expression txn; ferroptosis; txn ... See more keywords
Loss of interferon regulatory factor-1 prevents lung fibrosis by upregulation of pon1 expression
Sign Up to like & getrecommendations! Published in 2024 at "Respiratory Research"
DOI: 10.1186/s12931-024-02987-9
Abstract: Interferon regulatory factor-1 (IRF1) is a transcription factor that plays a significant role in various biological processes, including inflammatory injury, viral infection, cell death, and immune responses, and it has been extensively studied in the… read more here.
Keywords: mice; fibrosis; irf1; factor ... See more keywords
IFI35 is involved in the regulation of the radiosensitivity of colorectal cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Cell International"
DOI: 10.1186/s12935-021-01997-7
Abstract: Background Interferon regulatory factor-1 (IRF1) affects the proliferation of colorectal cancer (CRC). Recombinant interferon inducible protein 35 (IFI35) participates in immune regulation and cell proliferation. The aim of the study was to examine whether IRF1… read more here.
Keywords: colorectal cancer; ifi35; crc; irf1 ... See more keywords
Interferon Regulatory Factor-1 (IRF1) activates autophagy to promote liver ischemia/reperfusion injury by inhibiting β-catenin in mice
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0239119
Abstract: Autophagy is an important factor in liver ischemia-reperfusion injury. In the current study we investigate the function of interferon regulatory factor-1 (IRF1) in regulating autophagy to promote hepatic ischemia reperfusion injury (IR). The high expression… read more here.
Keywords: reperfusion injury; catenin; ischemia reperfusion; irf1 ... See more keywords
Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1009220
Abstract: The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I interferon genes. However, subsequent studies using genetic knockouts… read more here.
Keywords: interferon regulatory; regulatory factor; irf1 anti; factor irf1 ... See more keywords