Verteporfin Inhibits PD-L1 through Autophagy and the STAT1–IRF1–TRIM28 Signaling Axis, Exerting Antitumor Efficacy
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DOI: 10.1158/2326-6066.cir-19-0159
Abstract: Antibody blockade of PD-L1 is associated with toxicities, thus new targeting strategies are needed. Verteporfin suppresses PD-L1 expression via Golgi-related autophagy and disruption of STAT1–IRF1–TRIM28 signaling. Programmed cell death 1 ligand 1 (PD-L1) is a… read more here.
Keywords: irf1 trim28; stat1 irf1; trim28 signaling; verteporfin ... See more keywords