LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "irf3" as a keyword



Photo by cdc from unsplash

ID2 inhibits innate antiviral immunity by blocking TBK1- and IKKε-induced activation of IRF3

Sign Up to like & get
recommendations! Published in 2022 at "Science Signaling"

DOI: 10.1126/scisignal.abh0068

Abstract: Description ID2 reduces the interferon response to viral infections by inhibiting the activation of IRF3. ID2 interferes with IRF3 activation Inhibitor of DNA binding protein 2 (ID2) controls the development and differentiation of various immune… read more here.

Keywords: id2; infection; tbk1 ikk; irf3 ... See more keywords

Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b

Sign Up to like & get
recommendations! Published in 2022 at "Science Translational Medicine"

DOI: 10.1126/scitranslmed.abh3831

Abstract: Inflammation has profound but poorly understood effects on metabolism, especially in the context of obesity and nonalcoholic fatty liver disease (NAFLD). Here, we report that hepatic interferon regulatory factor 3 (IRF3) is a direct transcriptional… read more here.

Keywords: ppp2r1b; glucose homeostasis; irf3; obesity ... See more keywords
Photo by charlesdeluvio from unsplash

LYAR suppresses interferon-β induction by targeting phosphorylated IRF3.

Sign Up to like & get
recommendations! Published in 2019 at "Journal of virology"

DOI: 10.1128/jvi.00769-19

Abstract: The innate immune response is vital for host defense and must be tightly controlled, but the mechanisms responsible for its negative regulation have not been fully understood. The cell growth-regulating nucleolar protein (LYAR) has been… read more here.

Keywords: lyar; innate immune; irf3; immune responses ... See more keywords
Photo from wikipedia

eIF4A3 Promotes RNA Viruses’ Replication by Inhibiting Innate Immune Responses

Sign Up to like & get
recommendations! Published in 2022 at "Journal of Virology"

DOI: 10.1128/jvi.01513-22

Abstract: Production of type I IFN is pivotal for the cellular antiviral immunity. Virus infection leads to the activation of transcription factor IRF3 and subsequent production of type I IFN to eliminate viral infection. ABSTRACT Viral… read more here.

Keywords: immune responses; irf3; ifn; type ifn ... See more keywords

High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon Expression

Sign Up to like & get
recommendations! Published in 2022 at "Journal of Virology"

DOI: 10.1128/jvi.01875-21

Abstract: Persistent HPV infections can be associated with the development of several cancers. The ability to persist depends on the ability of the virus to escape the host immune system. ABSTRACT Persistent infection with some mucosal… read more here.

Keywords: hpv5 hpv8; irf3; hpv8 proteins; hpv16 ... See more keywords
Photo by kellysikkema from unsplash

DDX56 inhibits type I interferon by disrupting assembly of IRF3–IPO5 to inhibit IRF3 nucleus import

Sign Up to like & get
recommendations! Published in 2019 at "Journal of Cell Science"

DOI: 10.1242/jcs.230409

Abstract: ABSTRACT Transcription factor IRF3-mediated type I interferon induction plays a role in antiviral innate immunity. However, mechanisms for the control and regulation of IRF3 nuclear import remain largely unknown. We have identified DEAD box polypeptide… read more here.

Keywords: irf3 nucleus; ddx56; type interferon; irf3 ... See more keywords
Photo by vidarnm from unsplash

IRF3-mediated pathogenicity in a murine model of human hepatitis A

Sign Up to like & get
recommendations! Published in 2021 at "PLoS Pathogens"

DOI: 10.1371/journal.ppat.1009960

Abstract: HAV-infected Ifnar1-/- mice recapitulate many of the cardinal features of hepatitis A in humans, including serum alanine aminotransferase (ALT) elevation, hepatocellular apoptosis, and liver inflammation. Previous studies implicate MAVS-IRF3 signaling in pathogenesis, but leave unresolved… read more here.

Keywords: hav; irf3; irf3 mediated; ifnar1 mice ... See more keywords
Photo by nci from unsplash

GLCCI1 Deficiency Induces Glucocorticoid Resistance via the Competitive Binding of IRF1:GRIP1 and IRF3:GRIP1 in Asthma

Sign Up to like & get
recommendations! Published in 2021 at "Frontiers in Medicine"

DOI: 10.3389/fmed.2021.686493

Abstract: GLCCI1 plays a significant role in modulating glucocorticoid (GC) sensitivity in asthma. This project determines the underlying mechanism that GLCCI1 deficiency attenuates GC sensitivity in dexamethasone (Dex)-treated Ovalbumin (OVA)-induced asthma mice and epithelial cells through… read more here.

Keywords: grip1 irf3; glcci1 deficiency; irf3; grip1 ... See more keywords