IRF3-mediated pathogenicity in a murine model of human hepatitis A
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DOI: 10.1371/journal.ppat.1009960
Abstract: HAV-infected Ifnar1-/- mice recapitulate many of the cardinal features of hepatitis A in humans, including serum alanine aminotransferase (ALT) elevation, hepatocellular apoptosis, and liver inflammation. Previous studies implicate MAVS-IRF3 signaling in pathogenesis, but leave unresolved… read more here.
Keywords: hav; irf3; irf3 mediated; ifnar1 mice ... See more keywords