Point mutation L116R in interferon‐regulatory factor 4 differentially impacts key cytokine production in Th2, Th9, and Th17 cells
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202249869
Abstract: Upon first activation, CD4+ T cells differentiate into specialized T helper subtypes, dependent on the key transcription factors (TFs) T-bet for Th1, GATA3 for Th2, PU.1 for Th9, and RORγt for Th17. Our group established… read more here.
Keywords: irf4; th17 cells; th9; production ... See more keywords
Dissecting the impact of bromodomain inhibitors on the Interferon Regulatory Factor 4‐MYC oncogenic axis in multiple myeloma
Sign Up to like & getrecommendations! Published in 2022 at "Hematological Oncology"
DOI: 10.1002/hon.3016
Abstract: B‐cell progenitor fate determinant interferon regulatory factor 4 (IRF4) exerts key roles in the pathogenesis and progression of multiple myeloma (MM), a currently incurable plasma cell malignancy. Aberrant expression of IRF4 and the establishment of… read more here.
Keywords: irf4; cell; myc; interferon regulatory ... See more keywords
KDM3A inhibition modulates macrophage polarization to aggravate post-MI injuries and accelerates adverse ventricular remodeling via an IRF4 signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2019.109415
Abstract: It has been reported that KDM3A participates in several cardiovascular diseases through epigenetic mechanisms. However, its biological role post myocardial infarction (MI) has not been explored. Excessive and prolonged inflammation period can aggravate post-MI injuries… read more here.
Keywords: macrophage polarization; post injuries; polarization; post ... See more keywords
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2017.11.003
Abstract: Summary CD4+ T cells orchestrate immune responses and destruction of allogeneic organ transplants, but how this process is regulated on a transcriptional level remains unclear. Here, we demonstrated that interferon regulatory factor 4 (IRF4) was… read more here.
Keywords: irf4; cell dysfunction; cell; cd4 cell ... See more keywords
Feeling Exhausted? Tuning Irf4 Energizes Dysfunctional T Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2017.11.028
Abstract: The regulatory mechanisms governing T cell exhaustion remain incompletely understood. Man et al. (2017) and Wu et al. (2017) report that the T cell receptor responsive transcription factor Irf4 promotes T cell exhaustion in chronic viral infection but dampens exhaustion… read more here.
Keywords: feeling exhausted; exhausted tuning; energizes dysfunctional; irf4 energizes ... See more keywords
LMP1 signaling pathway activates IRF4 in latent EBV infection and a positive circuit between PI3K and Src is required
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.380
Abstract: Interferon (IFN) regulatory factors (IRFs) have crucial roles in immune regulation and oncogenesis. We have recently shown that IRF4 is activated through c-Src-mediated tyrosine phosphorylation in virus-transformed cells. However, the intracellular signaling pathway triggering Src… read more here.
Keywords: pi3k; lmp1 signaling; signaling pathway; activation ... See more keywords
Overexpression of CD49d in trisomy 12 chronic lymphocytic leukemia patients is mediated by IRF4 through induction of IKAROS
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-018-0296-5
Abstract: In chronic lymphocytic leukemia (CLL), homing and retention of leukemic cells inside tissue niches represent crucial steps of disease progression. CLL trafficking from bloodstream into microenvironments is actively coordinated by transient interactions with endothelium through… read more here.
Keywords: cll; lymphocytic leukemia; cd49d; chronic lymphocytic ... See more keywords
Shortening the Half-Life of IgG as a Strategy for Decreasing Alloantibodies.
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation"
DOI: 10.1097/tp.0000000000002091
Abstract: demonstrated that the absence of IRF4 leads to deficient immune responses in infection and autoimmune disease. In the study from Wu and co-workers, IRF4 was investigated in the context of transplantation. In a mouse model… read more here.
Keywords: igg strategy; shortening half; life igg; transplantation ... See more keywords
Interferon regulatory factor 4 dictates metabolic flexibility of fat versus muscle loss during repeated intermittent fasting
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731581
Abstract: Interferon regulatory factor 4 (IRF4) is a transcription factor that regulates the proliferation, differentiation, and metabolism of immune cells, such as macrophages and T cells. Recently, IRF4 has been shown to regulate lipolysis in adipocytes… read more here.
Keywords: irf4; irf4 knockout; muscle; physiology ... See more keywords
Abstract 1523: Repression of IRF4 and CYTIP unleashes anti-tumor interferon response in CDK4 inhibitor therapy in mantle cell lymphoma
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1523
Abstract: Inhibition of CDK4/6 has emerged as an effective cancer therapy, but the underlying mechanism remains obscure. We have addressed this question in mantle cell lymphoma (MCL), a Non-Hodgkin9s B cell lymphoma that remains incurable due… read more here.
Keywords: response; cdk4; repression; therapy ... See more keywords
Interferon Regulatory Factor 4 (IRF4) Promotes Lipopolysaccharide-Induced Colonic Mucosal Epithelial Cell Proliferation by Regulating Macrophage Polarization
Sign Up to like & getrecommendations! Published in 2022 at "European Surgical Research"
DOI: 10.1159/000525753
Abstract: Introduction: Ulcerative colitis (UC) is a chronic disease characterized by diffuse inflammation of the mucosa of colon and rectum. Interferon regulatory factor 4 (IRF4) mediates macrophage anti-inflammatory phenotype (alternatively activated macrophages [M2]). This study aimed… read more here.
Keywords: irf4; mucosal epithelial; cell; proliferation ... See more keywords