Association of interferon regulatory factor 5 (IRF5) gene polymorphisms with juvenile idiopathic arthritis
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Rheumatology"
DOI: 10.1007/s10067-018-4010-9
Abstract: Interferon regulatory factor 5 (IRF5) is a member of IRF family which induce signaling pathways and are involved in modulation of cell growth, differentiation, apoptosis, and immune system activity. Juvenile idiopathic arthritis (JIA) is an… read more here.
Keywords: irf5; jia; factor irf5; interferon regulatory ... See more keywords
IRF5 Signaling in Phagocytes Is Detrimental to Neonatal Hypoxic Ischemic Encephalopathy
Sign Up to like & getrecommendations! Published in 2020 at "Translational Stroke Research"
DOI: 10.1007/s12975-020-00832-x
Abstract: Immune responses to neonatal hypoxic ischemic encephalopathy (HIE) exacerbate brain injury. Phagocytes, including microglia, play a central role in the immune response, but how the activation of phagocytes is regulated remains elusive. Previously, we have… read more here.
Keywords: irf5; hypoxic ischemic; ischemic encephalopathy; neonatal hypoxic ... See more keywords
Coordination between innate immune cells, type I IFNs and IRF5 drives SLE pathogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Cytokine"
DOI: 10.1016/j.cyto.2019.05.018
Abstract: Systemic lupus erythematosus (SLE) is a complex autoimmune disease which affects multiple organs. The type I interferon (IFN) gene signature and circulating autoantibodies are hallmarks of SLE. Plasmacytoid dendritic cells (pDCs) are considered the main… read more here.
Keywords: immune; irf5; sle; type ifn ... See more keywords
Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09283-x
Abstract: During infection, transcription factor interferon regulatory factor 5 (IRF5) is essential for the control of host defense. Here we show that the microtubule-associated guanine nucleotide exchange factor (GEF)-H1, is required for the phosphorylation of IRF5… read more here.
Keywords: irf5; gef; recognition; activation irf5 ... See more keywords
IRF5 suppresses metastasis through the regulation of tumor-derived extracellular vesicles and pre-metastatic niche formation
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-66168-w
Abstract: Metastasis is driven by extensive cooperation between a tumor and its microenvironment, resulting in the adaptation of molecular mechanisms that evade the immune system and enable pre-metastatic niche (PMN) formation. Little is known of the… read more here.
Keywords: pre metastatic; tumor derived; tumor; irf5 ... See more keywords
#1213 Interferon regulatory factor 5 in myeloid cells promotes obstructive nephropathy-induced renal fibrosis in vivo
Sign Up to like & getrecommendations! Published in 2025 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaf116.0428
Abstract: Obstructive nephropathy is one of the main causes of chronic kidney disease, which may progress to end stage renal disease, leading to heavy medical burden. The main pathological characteristics of obstructive nephropathy is fibrosis. The… read more here.
Keywords: mice; fibrosis; renal fibrosis; obstructive nephropathy ... See more keywords
MicroRNA‐22‐3p alleviates spinal cord ischemia/reperfusion injury by modulating M2 macrophage polarization via IRF5
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15042
Abstract: Cell death after spinal cord ischemia/reperfusion (I/R) can occur through necrosis, apoptosis, and autophagy, resulting in changes to the immune environment. However, the molecular mechanism of this immune regulation is not clear. Accumulating evidence indicates… read more here.
Keywords: irf5; cord; mir; cord injury ... See more keywords
Monoallelic IRF5 deficiency in B cells prevents murine lupus
Sign Up to like & getrecommendations! Published in 2021 at "JCI Insight"
DOI: 10.1172/jci.insight.141395
Abstract: Gain-of-function polymorphisms in the transcription factor IFN regulatory factor 5 (IRF5) are associated with an increased risk of developing systemic lupus erythematosus. However, the IRF5-expressing cell type(s) responsible for lupus pathogenesis in vivo is not… read more here.
Keywords: irf5; deficiency cells; monoallelic irf5; murine lupus ... See more keywords
IRF5 is increased in labouring myometrium and regulates pro-labour mediators.
Sign Up to like & getrecommendations! Published in 2018 at "Reproduction"
DOI: 10.1530/rep-18-0140
Abstract: Preterm birth continues to be the leading cause of neonatal mortality and morbidities that can extend into adult life. Few treatment options stem from our incomplete understanding of the mechanisms of human labour and delivery.… read more here.
Keywords: irf5; labour mediators; expression; pro inflammatory ... See more keywords
Transforming Growth Factor-β1 Promotes M1 Alveolar Macrophage Polarization in Acute Lung Injury by Up-Regulating DNMT1 to Mediate the microRNA-124/PELI1/IRF5 Axis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.693981
Abstract: Objective Macrophages function as key orchestrators in the pathogenesis of acute lung injury (ALI). The current study sets out to investigate the molecular mechanism of transforming growth factor-β (TGFβ1) in the regulation of M1 alveolar… read more here.
Keywords: irf5; alveolar macrophage; macrophage polarization; polarization ... See more keywords
B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.01938
Abstract: Upon recognition of antigen, B cells undergo rapid proliferation followed by differentiation to specialized antibody secreting cells (ASCs). During this transition, B cells are reliant upon a multilayer transcription factor network to achieve a dramatic… read more here.
Keywords: irf5; proliferation; cell activation; differentiation ... See more keywords