Hepatic Interferon Regulatory Factor 6 Alleviates Liver Steatosis and Metabolic Disorder by Transcriptionally Suppressing Peroxisome Proliferator‐Activated Receptor γ in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30559
Abstract: Nonalcoholic fatty liver disease (NAFLD) has become a worldwide epidemic. A large and growing unmet therapeutic need has inspired numerous studies in the field. Integrating the published genomic data available in the Gene Expression Omnibus… read more here.
Keywords: interferon regulatory; regulatory factor; irf6; mice ... See more keywords
Revisiting Sodium Hexafluoroiridates: Perspective Precursors for Electronic, Quantum, and Related Materials
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.1c02722
Abstract: The following salts have been synthesized and structurally characterized: Na2[IrF6]·2H2O (C2/m, a = 6.6327(4), b = 10.0740(6), c = 5.9283(5) Å, β = 122.3880(10)°) and Na3[IrF6]·2H2O (R-3, a = 7.5963(3), b = 7.5963(3), c =… read more here.
Keywords: sodium hexafluoroiridates; revisiting sodium; hexafluoroiridates perspective; irf6 ... See more keywords
Common variation near IRF6 is associated with IFN-β-induced liver injury in multiple sclerosis
Sign Up to like & getrecommendations! Published in 2018 at "Nature Genetics"
DOI: 10.1038/s41588-018-0168-y
Abstract: Multiple sclerosis (MS) is a disease of the central nervous system treated with disease-modifying therapies, including the biologic, interferon-β (IFN-β). Up to 60% of IFN-β-exposed MS patients develop abnormal biochemical liver test results1,2, and 1… read more here.
Keywords: liver injury; ifn; multiple sclerosis; irf6 ... See more keywords
Genetic variation of IRF6 and TGFA genes in an HIV-exposed newborn with non-syndromic cleft lip palate.
Sign Up to like & getrecommendations! Published in 2020 at "Oral diseases"
DOI: 10.1111/odi.13403
Abstract: We present here the first reported case of a non-syndromic cleft lip and palate (NSCLP) in an HIV-exposed newborn of a mother on antiretroviral therapy (ART) in Indonesia. Genetic testing was performed to confirm a… read more here.
Keywords: syndromic cleft; lip palate; non syndromic; irf6 ... See more keywords
IRF6 and SPRY4 Signaling Interact in Periderm Development
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Dental Research"
DOI: 10.1177/0022034517719870
Abstract: Rare mutations in IRF6 and GRHL3 cause Van der Woude syndrome, an autosomal dominant orofacial clefting disorder. Common variants in IRF6 and GRHL3 also contribute risk for isolated orofacial clefting. Similarly, variants within genes that… read more here.
Keywords: irf6 spry4; signaling interact; abnormal oral; irf6 ... See more keywords
IRF6 Enhances IFN-β Expression and Inhibits Viral Replication to Reduce the Severity of Herpetic Stromal Keratitis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s526580
Abstract: Purpose Herpes simplex virus type 1 (HSV-1) infection of the human eye can lead to herpes simplex keratitis, which is the leading cause of infectious blindness worldwide. Inflammation invading the corneal stroma causes herpetic stromal… read more here.
Keywords: viral replication; herpetic stromal; stromal keratitis; irf6 ... See more keywords
The NOTCH-RIPK4-IRF6-ELOVL4 Axis Suppresses Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15030737
Abstract: Simple Summary The aim of our study is to understand the signaling mechanisms behind the tumor suppressive function of RIPK4 (receptor-interacting serine/threonine protein kinase 4) in squamous cell carcinomas (SCCs) of skin, head, and neck… read more here.
Keywords: ripk4 irf6; squamous cell; ripk4; irf6 ... See more keywords
Exploring the Role of IRF6 in Perinatal Arterial Ischemic Stroke: A Case of a Newborn with Craniofacial Malformations
Sign Up to like & getrecommendations! Published in 2025 at "Genes"
DOI: 10.3390/genes16030271
Abstract: Background/Objectives: Ischemic arterial stroke (AIS) is a cerebrovascular event that can occur acutely within the first hours or days of life, presenting as a neurological emergency. To date, clearly defined genetic risk factors for AIS… read more here.
Keywords: ischemic stroke; stroke; role; irf6 ... See more keywords