Molecular characterization of yellow catfish (Pelteobagrus fulvidraco) IRF7 suggests involvement in innate immune response.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2020.103700
Abstract: Interferon regulatory factor 7 (IRF7) serves as a critical mediator in the regulation of type Ι interferon (IFN) response to invading pathogens. Here, an ortholog of IRF7 was characterized in yellow catfish (Pelteobagrus fulvidraco). The… read more here.
Keywords: response; irf7; pelteobagrus fulvidraco; yellow catfish ... See more keywords
Chicken interferon regulatory factor 7 (IRF7) can control ALV-J virus infection by triggering type I interferon production through affecting genes related with innate immune signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2021.104026
Abstract: In order to breed new birds with strong disease resistance, it is necessary to first understand the mechanism of avian antiviral response. Interferon regulatory factor 7 (IRF7) is not only a member of type I… read more here.
Keywords: infection; regulatory factor; interferon; signaling pathway ... See more keywords
Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0624-2
Abstract: Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER−) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due… read more here.
Keywords: chemotherapy; dormancy; breast cancer; irf7 ... See more keywords
Enterovirus D68 VP3 Targets the Interferon Regulatory Factor 7 To Inhibit Type I Interferon Response
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.04138-22
Abstract: EV-D68 is a globally emerging pathogen that causes severe respiratory illnesses. Here, we report that EV-D68 inhibits innate immune responses by targeting IRF7. Further investigations revealed that the structural protein VP3 inhibited the TRAF6-induced ubiquitination… read more here.
Keywords: vp3; interaction; d68; structural protein ... See more keywords
Role of Toll-like receptors and interferon regulatory factors in different experimental heart failure models of diverse etiology: IRF7 as novel cardiovascular stress-inducible factor
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0193844
Abstract: Heart failure (HF) is a leading cause of morbidity and mortality in the western world. Although optimal medical care and treatment is widely available, the prognosis of patients with HF is still poor. Toll-like receptors… read more here.
Keywords: heart; irf7; gene expression; etiology ... See more keywords
Swine IRF3/IRF7 attenuates inflammatory responses through TLR4 signaling pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18740
Abstract: To explore the role of IRF3/IRF7 during inflammatory responses, we investigated the effects of swine IRF3/IRF7 on TLR4 signaling pathway and inflammatory factors expression in porcine kidney epithelial PK15 cell lines. We successfully constructed eukaryotic… read more here.
Keywords: inflammatory responses; signaling pathway; irf7; tlr4 signaling ... See more keywords
Circular RNA circ0007360 Attenuates Gastric Cancer Progression by Altering the miR-762/IRF7 Axis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.789073
Abstract: Gastric cancer is a major health burden worldwide. Circular RNAs (circRNAs) are a novel family of noncoding RNAs that are involved in multiple types of cancers, including gastric cancer. As biological functions and the underlying… read more here.
Keywords: cancer; circ0007360; irf7; mir 762 ... See more keywords
H1N1 Influenza A Virus Protein NS2 Inhibits Innate Immune Response by Targeting IRF7
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14112411
Abstract: Influenza A virus (IAV) is a globally distributed zoonotic pathogen and causes a highly infectious respiratory disease with high morbidity and mortality in humans and animals. IAV has evolved various strategies to counteract the innate… read more here.
Keywords: irf7; immune response; innate immune; protein ns2 ... See more keywords
IRF7 inhibits the Warburg effect via transcriptional suppression of PKM2 in osteosarcoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.65255
Abstract: Osteosarcoma (OS) is a malignant bone tumor among adolescents and young adults. IRF7 belongs to the transcription factor family of interferon regulatory factors (IRFs) and has previously been described to function as a tumor suppressor… read more here.
Keywords: inhibits warburg; irf7 inhibits; osteosarcoma; warburg effect ... See more keywords