Critical Role for a Subset of Intestinal Macrophages in Shaping Gut Microbiota in Adult Zebrafish.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.09.025
Abstract: The gut microbiota is strongly influenced by environmental factors, although host contribution is far less understood. We leveraged macrophage-deficient interferon regulatory factor irf8 zebrafish mutants to investigate the role of macrophages in this process. In… read more here.
Keywords: adult; gut; intestinal macrophages; gut microbiota ... See more keywords
Structure and expression identification of Cherry Valley duck IRF8
Sign Up to like & getrecommendations! Published in 2021 at "Poultry Science"
DOI: 10.1016/j.psj.2021.101598
Abstract: Interferon regulatory factor 8 (IRF8) is also known as interferon (IFN) consensus sequence binding protein (ICSBP), which plays an important role in IFN signal transduction. In this study, we cloned the full-length coding sequence of… read more here.
Keywords: expression; irf8; cherry valley; valley duck ... See more keywords
Total cellular protein presence of the transcription factor IRF8 does not necessarily correlate with its nuclear presence.
Sign Up to like & getrecommendations! Published in 2017 at "Methods"
DOI: 10.1016/j.ymeth.2016.08.011
Abstract: The transcription factor interferon regulatory factor-8 (IRF8) plays an essential role in myeloid differentiation and lineage commitment, based largely on molecular and genetic studies. The detection of IRF8 in specific cell populations by flow cytometry… read more here.
Keywords: presence; total cellular; transcription factor; nuclear presence ... See more keywords
Identification of Macrophage-Associated Novel Drug Targets in Atherosclerosis Based on Integrated Transcriptome Features
Sign Up to like & getrecommendations! Published in 2024 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.4c01558
Abstract: BACKGROUND This study explores the pathological mechanisms of atherosclerosis (AS), focusing on the role of macrophages in its formation and development, and potential therapeutic targets. METHODS The heterogeneity of the AS single-cell data set GSE131778… read more here.
Keywords: cd86; irf8; drug; cell ... See more keywords
IRF8 as a Novel Marker to Differentiate Between CD30-Positive Large Cell Lymphomas.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of clinical pathology"
DOI: 10.1093/ajcp/aqac044
Abstract: OBJECTIVES Interferon regulatory factor 8 (IRF8) is a new biomarker shown to be positive in monocytic leukemias as well as in B cells. As a transcription factor, it plays a critical role in pre-B-cell differentiation… read more here.
Keywords: cd30 positive; cell; cell lymphomas; large cell ... See more keywords
Interferon regulatory factor 8 induces intrinsic functional changes in mature neutrophils.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiaf078
Abstract: Neutrophils are the first line of host defense. Neutrophils target invading pathogens by phagocytosis, generation of reactive oxygen species (ROS), neutrophil extracellular trap formation (NETosis) and cytokine production. Interferon regulatory factor 8 (IRF8) plays a… read more here.
Keywords: mature neutrophils; irf8; regulatory factor; interferon regulatory ... See more keywords
FC 042IRF8 IN CDC1 IS PROTECTIVE IN POST-ISCHEMIC ACUTE KIDNEY INJURY
Sign Up to like & getrecommendations! Published in 2021 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfab119.002
Abstract: Post-ischemic acute tubular necrosis is a common cause of acute kidney disease (AKD) and subsequent chronic kidney disease. In AKD, mononuclear phagocytes (MPCs) including conventional dendritic cells (cDCs) are present during the different phases of… read more here.
Keywords: akd; injury; kidney; irf8 ... See more keywords
P02.16.A IRF8-DRIVEN REPROGRAMMING OF THE IMMUNE MICROENVIRONMENT ENHANCES ANTI-TUMOR ADAPTIVE IMMUNITY AND REDUCES IMMUNOSUPPRESSION IN MURINE GLIOBLASTOMA
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae144.119
Abstract: Glioblastoma (GBM) has a highly immunosuppressive tumor immune microenvironment (TIME), largely mediated by myeloid-derived suppressor cells (MDSCs). Here, we utilized a retroviral replicating vector (RRV) to deliver Interferon Regulatory Factor 8 (IRF8), a master regulator… read more here.
Keywords: irf8; murine; culture; tumor ... See more keywords
IRF8-driven reprogramming of the immune microenvironment enhances anti-tumor adaptive immunity and reduces immunosuppression in murine glioblastoma.
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-oncology"
DOI: 10.1093/neuonc/noae149
Abstract: BACKGROUND Glioblastoma (GBM) has a highly immunosuppressive tumor immune microenvironment (TIME), largely mediated by myeloid-derived suppressor cells (MDSCs). Here, we utilized a retroviral replicating vector (RRV) to deliver Interferon Regulatory Factor 8 (IRF8), a master… read more here.
Keywords: irf8; murine; culture; tumor ... See more keywords
A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.08.11.503623
Abstract: Transcription factors play a determining role in lineage commitment and cell differentiation. Interferon regulatory factor 8 (IRF8), a hematopoietic transcription factor, is prominently upregulated in dendritic cells (DC) by autoactivation and controls DC differentiation and… read more here.
Keywords: irf8; negative feedback; element; differentiation ... See more keywords
IRF8 may be a useful marker for blastic plasmacytoid dendritic cell neoplasm, especially with weak CD123 expression.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cutaneous pathology"
DOI: 10.1111/cup.14439
Abstract: We highlight the utility of interferon regulatory factor 8 (IRF8), a novel marker of monocytic and dendritic cell lineages, in the diagnosis of a case of blastic plasmacytoid dendritic cell neoplasm (BPDCN) presenting initially in… read more here.
Keywords: marker; irf8; dendritic cell; expression ... See more keywords