Critical Role for a Subset of Intestinal Macrophages in Shaping Gut Microbiota in Adult Zebrafish.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.09.025
Abstract: The gut microbiota is strongly influenced by environmental factors, although host contribution is far less understood. We leveraged macrophage-deficient interferon regulatory factor irf8 zebrafish mutants to investigate the role of macrophages in this process. In… read more here.
Keywords: adult; gut; intestinal macrophages; gut microbiota ... See more keywords
Structure and expression identification of Cherry Valley duck IRF8
Sign Up to like & getrecommendations! Published in 2021 at "Poultry Science"
DOI: 10.1016/j.psj.2021.101598
Abstract: Interferon regulatory factor 8 (IRF8) is also known as interferon (IFN) consensus sequence binding protein (ICSBP), which plays an important role in IFN signal transduction. In this study, we cloned the full-length coding sequence of… read more here.
Keywords: expression; irf8; cherry valley; valley duck ... See more keywords
Total cellular protein presence of the transcription factor IRF8 does not necessarily correlate with its nuclear presence.
Sign Up to like & getrecommendations! Published in 2017 at "Methods"
DOI: 10.1016/j.ymeth.2016.08.011
Abstract: The transcription factor interferon regulatory factor-8 (IRF8) plays an essential role in myeloid differentiation and lineage commitment, based largely on molecular and genetic studies. The detection of IRF8 in specific cell populations by flow cytometry… read more here.
Keywords: presence; total cellular; transcription factor; nuclear presence ... See more keywords
IRF8 as a Novel Marker to Differentiate Between CD30-Positive Large Cell Lymphomas.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of clinical pathology"
DOI: 10.1093/ajcp/aqac044
Abstract: OBJECTIVES Interferon regulatory factor 8 (IRF8) is a new biomarker shown to be positive in monocytic leukemias as well as in B cells. As a transcription factor, it plays a critical role in pre-B-cell differentiation… read more here.
Keywords: cd30 positive; cell; cell lymphomas; large cell ... See more keywords
FC 042IRF8 IN CDC1 IS PROTECTIVE IN POST-ISCHEMIC ACUTE KIDNEY INJURY
Sign Up to like & getrecommendations! Published in 2021 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfab119.002
Abstract: Post-ischemic acute tubular necrosis is a common cause of acute kidney disease (AKD) and subsequent chronic kidney disease. In AKD, mononuclear phagocytes (MPCs) including conventional dendritic cells (cDCs) are present during the different phases of… read more here.
Keywords: akd; injury; kidney; irf8 ... See more keywords
A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.08.11.503623
Abstract: Transcription factors play a determining role in lineage commitment and cell differentiation. Interferon regulatory factor 8 (IRF8), a hematopoietic transcription factor, is prominently upregulated in dendritic cells (DC) by autoactivation and controls DC differentiation and… read more here.
Keywords: irf8; negative feedback; element; differentiation ... See more keywords
IRF8 may be a useful marker for blastic plasmacytoid dendritic cell neoplasm, especially with weak CD123 expression.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cutaneous pathology"
DOI: 10.1111/cup.14439
Abstract: We highlight the utility of interferon regulatory factor 8 (IRF8), a novel marker of monocytic and dendritic cell lineages, in the diagnosis of a case of blastic plasmacytoid dendritic cell neoplasm (BPDCN) presenting initially in… read more here.
Keywords: marker; irf8; dendritic cell; expression ... See more keywords
Host Cells Actively Resist Porcine Reproductive and Respiratory Syndrome Virus Infection via the IRF8-MicroRNA-10a-SRP14 Regulatory Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00003-22
Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) has rapidly spread to the global pig industry and caused incalculable economic damage since first discovered in the 1980s. However, conventional vaccines do not provide satisfactory protection. ABSTRACT… read more here.
Keywords: prrsv infection; irf8; mir 10a; infection ... See more keywords
Abstract 4682: IRF8 controls T cell development and survival to regulate T cell antitumor activity
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4682
Abstract: Interferon Regulatory Factor 8 (IRF8, or ICSBP1) is a member of the Interferon Regulatory transcription factor family, and functions as a key hematopoietic transcription factor. Loss of IRF8 leads to defective antigen-presenting cell activity, perturbations… read more here.
Keywords: cell development; mice; cell; survival ... See more keywords
Potential Biomarkers and Drugs for Nanoparticle-Induced Cytotoxicity in the Retina: Based on Regulation of Inflammatory and Apoptotic Genes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph19095664
Abstract: The eye is a superficial organ directly exposed to the surrounding environment. Thus, the toxicity of nanoparticle (NP) pollutants to the eye may be potentially severer relative to inner organs and needs to be monitored.… read more here.
Keywords: irf8; stat3; irf8 socs3; ccl2 cxcl10 ... See more keywords