MafK mediates chromatin remodeling to silence IRF8 expression in non-immune cells in a cell-type specific manner.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.06.005
Abstract: The regulation of gene expression is a result of a complex interplay between chromatin remodeling, transcription factors (TFs) and signaling molecules. Cell differentiation is accompanied by chromatin remodeling of specific loci to permanently silence genes… read more here.
Keywords: mafk; chromatin remodeling; irf8 expression; expression ... See more keywords
Modulation of the tumor immune microenvironment by Interferon Regulatory Factor 8 enhances immunotherapy in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-94424-0
Abstract: Interferon regulatory factors (IRFs) are integral in governing the expression of Type I interferon (IFN) genes. However, the precise role of IRFs in lung adenocarcinoma remains elusive. Our objective is to elucidate the prognostic implications… read more here.
Keywords: irf8 expression; lung adenocarcinoma; response; interferon regulatory ... See more keywords