Coadministration of Oligomeric Hyaluronic Acid-Modified Liposomes with Tumor-Penetrating Peptide-iRGD Enhances the Antitumor Efficacy of Doxorubicin against Melanoma.
Sign Up to like & getrecommendations! Published in 2017 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.6b13738
Abstract: A safe and efficient tumor-targeting strategy based on oligomeric hyaluronic acid (HA) modification and coadministration of tumor-penetrating peptide-iRGD was successfully developed. In this study, common liposomes (cLip) were modified by oligomeric HA to obtain HA-Lip.… read more here.
Keywords: coadministration; tumor; irgd; dox ... See more keywords
Design of an Amphiphilic iRGD Peptide and Self-Assembling Nanovesicles for Improving Tumor Accumulation and Penetration and the Photodynamic Efficacy of the Photosensitizer.
Sign Up to like & getrecommendations! Published in 2018 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b11699
Abstract: Photodynamic therapy (PDT) is a minimally invasive treatment for many diseases, including infections and tumors. Nevertheless, clinical utilization of PDT is severely restricted due to the shortcomings of the photosensitizers, especially their low water solubility… read more here.
Keywords: irgd; penetration; photodynamic efficacy; self ... See more keywords
Antitumor activity of iRGD-modified red blood cell membrane nanoparticles loaded with Juglone and Oxaliplatin against colorectal cancer
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biomaterials Applications"
DOI: 10.1177/08853282211052386
Abstract: Poor solubility and non-specific biological distribution are critical obstacles for applying Juglone (Jug) into clinical practice. To improve the antitumor efficacy of Jug, an iRGDmodified red blood cell membrane (RBCm) platform was developed to package… read more here.
Keywords: jug; jug oxa; cell; irgd ... See more keywords
Topical ocular delivery to laser-induced choroidal neovascularization by dual internalizing RGD and TAT peptide-modified nanoparticles
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s126865
Abstract: A nanoparticle (NP) was developed to target choroidal neovascularization (CNV) via topical ocular administration. The NPs were prepared through conjugation of internalizing arginine-glycine-aspartic acid RGD (iRGD; Ac-CCRGDKGPDC) and transactivated transcription (TAT) (RKKRRQRRRC) peptide to polymerized… read more here.
Keywords: choroidal neovascularization; irgd; irgd tat; modified nps ... See more keywords
Combined Self-Assembled iRGD Polymersomes for Effective Targeted siRNA Anti-Tumor Therapy
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s383862
Abstract: Introduction iRGD is usually used as a motif to modify siRNA-nanodelivery vectors to improve tumor-targeting and penetration. However, most of the modifications are realized by covalent conjugation, which normally requires complex preparation processes possibly with… read more here.
Keywords: irgd; effective targeted; irgd nps; targeted sirna ... See more keywords
Tumor penetrating peptide-functionalized Tenascin-C antibody for glioblastoma targeting.
Sign Up to like & getrecommendations! Published in 2020 at "Current cancer drug targets"
DOI: 10.2174/1568009620666201001112749
Abstract: BACKGROUND Conjugation to clinical-grade tumor penetrating iRGD peptide is a widely used strategy to improve tumor homing, extravasation, and penetration of cancer drugs and tumor imaging agents. The C domain of extracellular matrix molecule Tenascin-C… read more here.
Keywords: irgd; antibody; tumor penetrating; scfv g11 ... See more keywords
MicroRNA-539-5p-Loaded PLGA Nanoparticles Grafted with iRGD as a Targeting Treatment for Choroidal Neovascularization
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14020243
Abstract: Choroidal neovascularization (CNV) is a major cause of visual impairment that results from excessive growth of blood vessels in the eye’s choroid. The limited clinical efficacy of the current therapy for this condition requires the… read more here.
Keywords: irgd; plga; plga nps; mir 539 ... See more keywords