Irgm2 and Gate‐16 cooperatively dampen Gram‐negative bacteria‐induced caspase‐11 response
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DOI: 10.15252/embr.202050829
Abstract: Inflammatory caspase‐11 (rodent) and caspases‐4/5 (humans) detect the Gram‐negative bacterial component LPS within the host cell cytosol, promoting activation of the non‐canonical inflammasome. Although non‐canonical inflammasome‐induced pyroptosis and IL‐1‐related cytokine release are crucial to mount… read more here.
Keywords: canonical inflammasome; irgm2; gram negative; non canonical ... See more keywords
Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization
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DOI: 10.26508/lsa.202000960
Abstract: Irgm2 controls Toxoplasma killing via selective recruitment of Gbp1 and Irgb6 to Toxoplasma parasitophorous vacuoles, whereas its vacuolar localization is dispensable for parasite killing. Interferon-inducible GTPases, such as immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs),… read more here.
Keywords: irgm2; parasite killing; toxoplasma; vacuolar localization ... See more keywords