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Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-03845-3
Abstract: Membrane-tethered signalling proteins such as TNFα and many EGF receptor ligands undergo shedding by the metalloproteinase ADAM17 to get released. The pseudoproteases iRhom1 and iRhom2 are important for the transport, maturation and activity of ADAM17.…
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Keywords:
adam17;
egf receptor;
irhd;
homology domain ... See more keywords