Patient‐derived tumor organoids predict responses to irinotecan‐based neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34302
Abstract: Adding irinotecan to neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC) increases the pathologic complete response (pCR) rate but brings more toxicities. Robust biomarkers to predict response to irinotecan‐based nCRT are extremely necessary for… read more here.
Keywords: chemoradiotherapy; irinotecan based; pcr; cohort ... See more keywords
CT-based Radiomics for the Identification of Colorectal Cancer Liver Metastases Sensitive to First-Line Irinotecan-Based Chemotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Medical physics"
DOI: 10.1002/mp.16325
Abstract: BACKGROUND Chemosensitivity prediction in colorectal cancer patients with liver metastases has remained a research hotspot. Radiomics can extract features from patient imaging, and deep learning or machine learning can be used to build models to… read more here.
Keywords: liver metastases; irinotecan based; colorectal cancer; chemotherapy ... See more keywords
UGT1A polymorphisms associated with worse outcome in colorectal cancer patients treated with irinotecan-based chemotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-018-3595-7
Abstract: PurposeTo investigate the association between UDP-glucuronosyltransferase (UGT)1A polymorphisms and irinotecan-treatment efficacy in a Chinese population with metastatic colorectal cancer (mCRC).MethodsThe present study was based on a prospective multicenter trial of Chinese mCRC patients treated with… read more here.
Keywords: treated irinotecan; irinotecan based; patients treated; colorectal cancer ... See more keywords
Real-world safety and supportive care use of second-line 5-fluorouracil-based regimens among patients with metastatic pancreatic ductal adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Current medical research and opinion"
DOI: 10.1080/03007995.2022.2059976
Abstract: Objective Chemotherapy-related adverse events (AEs) can negatively impact the care of patients. The prevention and management of AEs often require additional medications. We evaluated the percentages of patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) undergoing… read more here.
Keywords: second line; based regimens; patients treated; liposomal irinotecan ... See more keywords
Examination of multiple UGT1A and DPYD polymorphisms has limited ability to predict the toxicity and efficacy of metastatic colorectal cancer treated with irinotecan-based chemotherapy: a retrospective analysis
Sign Up to like & getrecommendations! Published in 2017 at "BMC Cancer"
DOI: 10.1186/s12885-017-3406-2
Abstract: BackgroundTo evaluate a new UGT1A and DPYD polymorphism panel to better predict irinotecan-induced toxicity and the clinical response in Chinese patients with metastatic colorectal cancer (mCRC).MethodsThe genotypes of UGT1A (UGT1A1*6, UGT1A1*27, UGT1A1*28, UGT1A7*2, UGT1A7*3, UGT1A7*4… read more here.
Keywords: dpyd; ugt1a dpyd; irinotecan based; ugt1a1 ugt1a1 ... See more keywords
FOLFIRINOX versus sequential 5-FU, oxaliplatin, and irinotecan-based regimens in patients with recurrent pancreatic cancer (rPDAC).
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e16791
Abstract: e16791Background: There is a paucity of data to guide treatment for rPDAC after curative resection and gemcitabine-based adjuvant chemotherapy. Our aim was to investigate whether combination treatm... read more here.
Keywords: versus sequential; irinotecan based; sequential oxaliplatin; oxaliplatin irinotecan ... See more keywords