Irinotecan dosing and pharmacogenomics: a comprehensive exploration based on UGT1A1 variants and emerging insights
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DOI: 10.1080/1120009x.2024.2349444
Abstract: Abstract Irinotecan is a critical anticancer drug used to treat metastatic colorectal cancer and advanced pancreatic ductal adenocarcinoma by obstructing topoisomerase 1; however, it can cause minor-to-severe and life-threatening adverse effects. UDP glucuronosyltransferase family 1… read more here.
Keywords: pharmacogenomics comprehensive; exploration based; irinotecan dosing; dosing pharmacogenomics ... See more keywords