Pre-therapeutic UGT1A1 genotyping to reduce the risk of irinotecan-induced severe toxicity: Ready for prime time.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of cancer"
DOI: 10.1016/j.ejca.2020.09.007
Abstract: BACKGROUND Pre-therapeutic UGT1A1 genotyping is not yet routinely performed in most hospitals in patients starting irinotecan chemotherapy. The aim of this position paper was to evaluate the available evidence and to assess the potential value… read more here.
Keywords: irinotecan induced; induced severe; severe toxicity; pre therapeutic ... See more keywords
Role of regulatory T cells in irinotecan‐induced intestinal mucositis
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.01.006
Abstract: Abstract Intestinal mucositis (IM) is a common side effect of irinotecan‐based chemotherapy. The involvement of inflammatory mediators, such as TNF‐&agr;, IL1‐&bgr;, IL‐18 and IL‐33, has been demonstrated. However, the role of adaptive immune system cells,… read more here.
Keywords: irinotecan induced; intestinal mucositis; regulatory cells; role ... See more keywords
Paraprobiotic Enterococcus faecalis EC-12 prevents the development of irinotecan-induced intestinal mucositis in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Life sciences"
DOI: 10.1016/j.lfs.2022.120445
Abstract: AIMS This study tested the protective effect of purified paraprobiotic Enterococcus faecalis (EC-12) and an E. faecalis-based formulation (Med LanS) on irinotecan-induced intestinal mucositis murine model. MAIN METHODS C57BL/6 male mice received saline, irinotecan (75 mg/Kg,… read more here.
Keywords: mucositis; paraprobiotic enterococcus; faecalis; intestinal mucositis ... See more keywords
Mitochondrial DNA as a Possible Ligand for TLR9 in Irinotecan-induced Small Intestinal Mucositis
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Investigations"
DOI: 10.1080/08820139.2022.2026379
Abstract: ABSTRACT Cancer chemotherapy and radiotherapy may result in mucositis characterized by stem cell damage and inflammation in the gastrointestinal tract. The molecular mechanisms underlying this pathology remain unknown. Based on the assumption that mitochondrial CPG-DNA… read more here.
Keywords: dna; intestinal mucositis; pathology; irinotecan induced ... See more keywords
Incidence and non-genetic risk factors of irinotecan-induced severe neutropenia in Chinese adult inpatients
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DOI: 10.1097/md.0000000000033005
Abstract: To analyze the incidence and nongenetic risk factors of irinotecan-induced severe neutropenia in the hospital, and provide additional reference and help for clinical treatment. A retrospective analysis of patients who received irinotecan based chemotherapy from… read more here.
Keywords: induced severe; severe neutropenia; risk factors; analysis ... See more keywords
Luteolin prevents irinotecan‐induced intestinal mucositis in mice through antioxidant and anti‐inflammatory properties
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14987
Abstract: Intestinal mucositis refers to mucosal damage caused by cancer treatment, and irinotecan is one of the agents most associated with this condition. Focusing on the development of alternatives to prevent this important adverse effect, we… read more here.
Keywords: mucositis; irinotecan induced; prevents irinotecan; induced intestinal ... See more keywords
eIF3a‐PPP2R5A‐mediated ATM/ATR dephosphorylation is essential for irinotecan‐induced DNA damage response
Sign Up to like & getrecommendations! Published in 2022 at "Cell Proliferation"
DOI: 10.1111/cpr.13208
Abstract: The individual differences and pervasive resistance seriously hinder the optimization of irinotecan‐based therapeutic effectiveness. Eukaryotic translation initiation factor 3a (eIF3a) plays a key role in tumour occurrence, prognosis and therapeutic response. This study focused on… read more here.
Keywords: dna damage; eif3a; induced dna; response ... See more keywords
ERK activation and autophagy impairment are central mediators of irinotecan-induced steatohepatitis
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DOI: 10.1136/gutjnl-2016-312485
Abstract: Objective Preoperative chemotherapy with irinotecan is associated with the development of steatohepatitis, which increases the risk of perioperative morbidity and mortality for liver surgery. The molecular mechanisms of this chemotherapeutic complication are widely unknown. Design… read more here.
Keywords: autophagy impairment; irinotecan induced; erk activation; steatohepatitis ... See more keywords
Glucose Conferred Irinotecan Chemoresistance through Divergent Actions of Pyruvate and ATP in Cell Death and Proliferation of Colorectal Cancer
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DOI: 10.1159/000525977
Abstract: Background: Altered glucose metabolism is associated with chemoresistance in colorectal cancer (CRC). This study aimed to illustrate the molecular mechanisms of glucose-mediated chemoresistance against irinotecan, a topoisomerase I inhibitor, focusing on the distinct roles of… read more here.
Keywords: cell; irinotecan induced; proliferation; pyruvate atp ... See more keywords
Relation between irinotecan-induced cholinergic syndrome and prognosis of colorectal cancer patients.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.4_suppl.859
Abstract: 859Background: It is well known that a cetuximab induced rash is strongly associated with improved survival of colorectal cancer patients. Irinotecan Induced Cholinergic Syndrome (IICS), manifestin... read more here.
Keywords: cancer patients; irinotecan induced; colorectal cancer; cholinergic syndrome ... See more keywords
Systematic evaluation of irinotecan-induced intestinal mucositis based on metabolomics analysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.958882
Abstract: Chemotherapy-induced intestinal mucositis (CIM) is a major dose-limiting side effect of chemotherapy, especially in regimens containing irinotecan (CPT-11). Several studies on the pathologic mechanisms of CIM focused on both the genomics and molecular pathways triggered… read more here.
Keywords: induced intestinal; intestinal mucositis; analysis; systematic evaluation ... See more keywords