Association between UGT1A1 gene polymorphism and safety and efficacy of irinotecan monotherapy as the third-line treatment for advanced gastric cancer
Sign Up to like & getrecommendations! Published in 2018 at "Gastric Cancer"
DOI: 10.1007/s10120-018-00917-5
Abstract: BackgroundWhile uridine diphosphate glucuronosyltransferase (UGT) 1A1 is a key enzyme in the metabolism of irinotecan, relationship between UGT1A1 genotype and safety and efficacy of irinotecan monotherapy in patients with advanced gastric cancer is not clarified.MethodsEfficacy… read more here.
Keywords: irinotecan monotherapy; advanced gastric; gastric cancer; treatment ... See more keywords
Impact of single-heterozygous UGT1A1 on the clinical outcomes of irinotecan monotherapy after fluoropyrimidine and platinum-based combination therapy for gastric cancer: a multicenter retrospective study
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-020-01720-y
Abstract: It is unclear whether the UGT1A1 status, single heterozygous (SH) or wild type (WT), is associated with the efficacy and toxicity of irinotecan monotherapy in advanced gastric cancer (AGC). We investigated the association between clinical… read more here.
Keywords: irinotecan monotherapy; clinical outcomes; gastric cancer; single heterozygous ... See more keywords