The immunosuppressive microenvironment in BRCA1-IRIS-overexpressing TNBC tumors is induced by bidirectional interaction with tumor-associated macrophages.
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DOI: 10.1158/0008-5472.can-19-2374
Abstract: Tumor-associated macrophages (TAMs) promote triple-negative breast cancer (TNBC) progression. Here, we report BRCA1-IRIS overexpressing (IRISOE) TNBC cells secrete high levels of GM-CSF in a HIF-1a- and a NF-kB-dependent manner to recruit macrophages to IRISOE cells… read more here.
Keywords: tnbc cells; tnbc tumors; tnbc; interaction ... See more keywords