Anti-apoptotic activity of ETB receptor agonist, IRL-1620, protects neural cells in rats with cerebral ischemia
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DOI: 10.1038/s41598-019-46203-x
Abstract: Endothelin-B receptor agonist, IRL-1620, provides significant neuroprotection following cerebral ischemia in rats. Whether this neuroprotection is due to inhibition of apoptosis is unknown. IRL-1620-treated rats following permanent middle cerebral artery occlusion (MCAO) showed significant improvement… read more here.
Keywords: compared vehicle; vehicle; irl 1620; cerebral ischemia ... See more keywords
Sovateltide (IRL-1620) activates neuronal differentiation and prevents mitochondrial dysfunction in adult mammalian brains following stroke
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DOI: 10.1038/s41598-020-69673-w
Abstract: The development of effective drugs for stroke is urgently required as it is the 2nd largest killer in the world and its incidence is likely to increase in the future. We have demonstrated cerebral endothelin… read more here.
Keywords: sovateltide irl; activates neuronal; differentiation; 1620 activates ... See more keywords
Sovateltide (IRL-1620) affects neuronal progenitors and prevents cerebral tissue damage after ischemic stroke.
Sign Up to like & getrecommendations! Published in 2020 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2020-0164
Abstract: Stimulation of endothelin-B receptors by its agonist, IRL-1620 (INN: sovateltide), provides neuroprotection and neurological and motor function improvement following cerebral ischemia. We investigated the effect of sovateltide on stem and progenitor cells mediated neural regeneration… read more here.
Keywords: ischemic stroke; motor function; cerebral tissue; sovateltide ... See more keywords
Neuroprotective Effect of IRL-1620, an Endothelin B Receptor Agonist, on a Pediatric Rat Model of Middle Cerebral Artery Occlusion
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DOI: 10.3389/fped.2018.00310
Abstract: Objective: The purpose of this study was to determine the potential neuroprotective effect of endothelin B (ETB) receptor agonist IRL-1620 treatment in a pediatric model of ischemic stroke. Design: A prospective, animal model study. Setting:… read more here.
Keywords: receptor agonist; neuroprotective effect; model; irl 1620 ... See more keywords