Absorption of iron from Tegillarca granosa using an in vitro simulated digestion and Caco-2/HepG2 co-culture system.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12200
Abstract: BACKGROUND Iron deficiency anemia (IDA) is one severe micronutrient malnutrition and has captured worldwide attention. This study evaluated the in vitro iron absorption of two iron-binding proteins (hemoglobin and ferritin) from Tegillarca granosa (T. granosa).… read more here.
Keywords: hemoglobin ferritin; iron; granosa; iron absorption ... See more keywords
Zinc induces iron egress from intestinal Caco-2 cells via induction of Hephaestin: A role for PI3K in intestinal iron absorption.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.01.023
Abstract: In previous studies we demonstrated that zinc stimulates iron uptake in intestinal Caco-2 cells via Zinc-PI3K-IRP2-DMT1 axis. In the current study we investigated the effect of zinc on basolateral iron release and characterized the associated mechanisms.… read more here.
Keywords: caco cells; zinc; heph; expression ... See more keywords
Effect of procyanidin on dietary iron absorption in hereditary hemochromatosis and in dysmetabolic iron overload syndrome: A crossover double-blind randomized controlled trial.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2019.02.012
Abstract: BACKGROUND & AIMS Type I hereditary hemochromatosis (HH) and dysmetabolic iron overload syndrome (DIOS) are the two most prevalent iron overload diseases. Although many food components, particularly polyphenols, reduce iron bioavailability, there is no clinically… read more here.
Keywords: iron; iron absorption; dietary iron; iron overload ... See more keywords
Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2018.06.006
Abstract: Background & Aims Multicopper ferroxidases (MCFs) facilitate intestinal iron absorption and systemic iron recycling, likely by a mechanism involving the oxidization of Fe2+ from the iron exporter ferroportin 1 for delivery to the circulating Fe3+… read more here.
Keywords: multicopper ferroxidases; intestinal iron; mice; iron ... See more keywords
Iron Absorption: Factors, Limitations, and Improvement Methods
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DOI: 10.1021/acsomega.2c01833
Abstract: Iron is an essential element for human life since it participates in many functions in the human body, including oxygen transport, immunity, cell division and differentiation, and energy metabolism. Iron homeostasis is mainly controlled by… read more here.
Keywords: iron bioavailability; iron; iron deficiency; iron absorption ... See more keywords
Structural basis for promotion of duodenal iron absorption by enteric ferric reductase with ascorbate
Sign Up to like & getrecommendations! Published in 2018 at "Communications Biology"
DOI: 10.1038/s42003-018-0121-8
Abstract: Dietary iron absorption is regulated by duodenal cytochrome b (Dcytb), an integral membrane protein that catalyzes reduction of nonheme Fe3+ by electron transfer from ascorbate across the membrane. This step is essential to enable iron… read more here.
Keywords: absorption; structural basis; ascorbate; iron ... See more keywords
Effects of dietary fiber on intestinal iron absorption, and physiological status: a systematic review of in vivo and clinical studies.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in food science and nutrition"
DOI: 10.1080/10408398.2022.2060933
Abstract: The benefits of dietary fiber on intestinal health have been well established. However, there is no consensus on the dietary fiber effects on mineral absorption. The objective of this systematic review is to discuss the… read more here.
Keywords: iron absorption; absorption; dietary fiber; status ... See more keywords
The Effect of Prebiotics on Human Iron Absorption: A Review.
Sign Up to like & getrecommendations! Published in 2022 at "Advances in nutrition"
DOI: 10.1093/advances/nmac079
Abstract: Iron deficiency remains the most common nutritional deficiency. Oral iron supplementation is the recommended first-line treatment and used as a preventive measure as well. Enhancers of iron absorption are highly sought after to improve supplementation… read more here.
Keywords: review; iron absorption; iron; effect prebiotics ... See more keywords
A Review of Nutrients and Compounds, Which Promote or Inhibit Intestinal Iron Absorption: Making a Platform for Dietary Measures That Can Reduce Iron Uptake in Patients with Genetic Haemochromatosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Nutrition and Metabolism"
DOI: 10.1155/2020/7373498
Abstract: Objective To provide an overview of nutrients and compounds, which influence human intestinal iron absorption, thereby making a platform for elaboration of dietary recommendations that can reduce iron uptake in patients with genetic haemochromatosis. Design… read more here.
Keywords: iron uptake; reduce iron; haemochromatosis; iron ... See more keywords
Novel Iron-Whey Protein Microspheres Protect Gut Epithelial Cells from Iron-Related Oxidative Stress and Damage and Improve Iron Absorption in Fasting Adults
Sign Up to like & getrecommendations! Published in 2017 at "Acta Haematologica"
DOI: 10.1159/000480632
Abstract: Background: Iron food fortification and oral iron formulations are frequently limited by poor absorption, resulting in the widespread use of high-dose oral iron, which is poorly tolerated. Methods: We evaluated novel iron-denatured whey protein (Iron-WP)… read more here.
Keywords: absorption; whey protein; iron; novel iron ... See more keywords
Duodenal macrophages control dietary iron absorption via local degradation of transferrin.
Sign Up to like & getrecommendations! Published in 2023 at "Blood"
DOI: 10.1182/blood.2022016632
Abstract: Iron is an essential cellular metal that is important for many physiological functions including erythropoiesis and host defense. It is absorbed from the diet in the duodenum and loaded onto transferrin, the main iron transport… read more here.
Keywords: dietary iron; transferrin; iron; local degradation ... See more keywords