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Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.29062
Abstract: Higher nigral iron has been reported in Parkinson's disease (PD).
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Keywords:
dynamics nigral;
nigral iron;
parkinson disease;
iron accumulation ... See more keywords
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Published in 2017 at "Clinical Neuroradiology"
DOI: 10.1007/s00062-017-0605-9
Abstract: Neurodegeneration with brain iron accumulation (NBIA) is a heterogeneous group of inherited neurologic disorders with iron accumulation in the basal ganglia, which share magnetic resonance (MR) imaging characteristics, histopathologic and clinical features. According to the affected…
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Keywords:
neurodegeneration;
brain iron;
neurodegeneration brain;
iron accumulation ... See more keywords
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1
Published in 2018 at "Biological Trace Element Research"
DOI: 10.1007/s12011-018-1332-z
Abstract: Sarcopenia has a high incidence among the elderly, with significant negative effects on the quality of life. The pathogenesis of sarcopenia is complex, and many factors are involved in its development and progression. Sarcopenia might…
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Keywords:
sarcopenia;
possible risk;
iron accumulation;
iron ... See more keywords
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Published in 2017 at "European journal of medical genetics"
DOI: 10.1016/j.ejmg.2017.08.015
Abstract: Defects of phospholipids remodelling and synthesis are inborn errors of metabolism responsible for various clinical presentations including spastic paraplegia, retinopathy, optic atrophy, myo- and cardiomyopathies, and osteo-cutaneous manifestations. DDHD1 encodes a phospholipase A1, which is…
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Keywords:
mutations ddhd1;
neurodegeneration brain;
phospholipase;
brain iron ... See more keywords
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Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.10.017
Abstract: Previous MRI studies reported cortical iron accumulation in early-onset (EOAD) compared to late-onset (LOAD) Alzheimer disease patients. However, the pattern and origin of iron accumulation is poorly understood. This study investigated the histopathological correlates of…
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Keywords:
cortical myelin;
alzheimer disease;
iron accumulation;
histology ... See more keywords
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Published in 2018 at "Redox Biology"
DOI: 10.1016/j.redox.2017.08.015
Abstract: Cellular senescence is characterised by the irreversible arrest of proliferation, a pro-inflammatory secretory phenotype and evasion of programmed cell death mechanisms. We report that senescence alters cellular iron acquisition and storage and also impedes iron-mediated…
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Keywords:
iron;
ferroptosis;
senescent cells;
iron accumulation ... See more keywords
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Published in 2021 at "Stem cell research"
DOI: 10.1016/j.scr.2021.102190
Abstract: Neurodegeneration with brain iron accumulation (NBIA) is a genetically and phenotypically heterogeneous group of inherited neurodegenerative disorder characterized by basal ganglia iron deposition. Mutations in Pantothenate Kinase 2 (PANK2) are major genetic causes for patients…
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Keywords:
neurodegeneration brain;
brain iron;
accumulation nbia;
iron accumulation ... See more keywords
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Published in 2023 at "Cardiology in the young"
DOI: 10.1017/s1047951122004206
Abstract: AIM Beta-thalassemia major requires regular blood transfusions throughout life, which in turn leads to iron accumulation in the body. While cardiac T2* MRI is the gold standard in determining cardiac iron accumulation, it is not…
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Keywords:
thalassemia major;
iron;
differentiation factor;
iron accumulation ... See more keywords
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Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13029-4
Abstract: Proteins involved in iron homeostasis have been identified as biomarkers for lupus nephritis, a serious complication of systemic lupus erythematosus (SLE). We tested the hypothesis that renal iron accumulation occurs and contributes to renal injury…
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Keywords:
accumulation;
renal iron;
lupus nephritis;
mice ... See more keywords
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1
Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13694
Abstract: Progressive iron accumulation in the substantia nigra in the aged human brain is a major risk factor for Parkinson's disease and other neurodegenerative diseases. Heavy metals, such as iron, produce reactive oxygen species and consequently…
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Keywords:
substantia nigra;
iron;
iron accumulation;
accumulation ... See more keywords
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Published in 2023 at "Brain pathology"
DOI: 10.1111/bpa.13158
Abstract: Neuroinflammation has been implicated in frontotemporal lobar degeneration (FTLD) pathophysiology, including in genetic forms with microtubule-associated protein tau (MAPT) mutations (FTLD-MAPT) or chromosome 9 open reading frame 72 (C9orf72) repeat expansions (FTLD-C9orf72). Iron accumulation as a…
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Keywords:
ftld mapt;
iron;
cortical iron;
iron accumulation ... See more keywords