Heme-iron acquisition in fungi.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2019.05.006
Abstract: Heme is a bioavailable source of iron, for which different fungi have evolved several distinct acquisition mechanisms. In the iron-scarce animal host, in particular, microbial pathogens are able to utilize the large heme pool of… read more here.
Keywords: heme; acquisition fungi; heme iron; iron acquisition ... See more keywords
The Emerging Role of Iron Acquisition in Biofilm-Associated Infections.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in microbiology"
DOI: 10.1016/j.tim.2021.02.009
Abstract: A possible association between iron and biofilm formation has been explored for a long time. Here, we focus on major recent advances that shed light on the mechanisms behind this relationship and discuss how siderophore-mediated… read more here.
Keywords: emerging role; biofilm; iron acquisition; iron ... See more keywords
Iron Acquisition Systems of Gram-negative Bacterial Pathogens Define TonB-Dependent Pathways to Novel Antibiotics.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.0c01005
Abstract: Iron is an indispensable metabolic cofactor in both pro- and eukaryotes, which engenders a natural competition for the metal between bacterial pathogens and their human or animal hosts. Bacteria secrete siderophores that extract Fe3+ from… read more here.
Keywords: acquisition systems; gram negative; negative bacterial; systems gram ... See more keywords
Transcript Profiling of Nitroxoline-Treated Biofilms Shows Rapid Up-regulation of Iron Acquisition Gene Clusters.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.2c00206
Abstract: Bacterial biofilms are surface-attached communities of slow- or non-replicating cells embedded within a protective matrix of biomolecules. Unlike free-floating planktonic bacteria, biofilms are innately tolerant to conventional antibiotics and are prevalent in recurring and chronic… read more here.
Keywords: iron acquisition; nitroxoline; gene clusters; transcript profiling ... See more keywords
Iron acquisition system of Sphingobium sp. strain SYK-6, a degrader of lignin-derived aromatic compounds
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-68984-2
Abstract: Iron, an essential element for all organisms, acts as a cofactor of enzymes in bacterial degradation of recalcitrant aromatic compounds. The bacterial family, Sphingomonadaceae comprises various degraders of recalcitrant aromatic compounds; however, little is known… read more here.
Keywords: iron acquisition; iron; aromatic compounds; acquisition system ... See more keywords
The chemical ecology of coumarins and phenazines affects iron acquisition by pseudomonads.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2217951120
Abstract: Secondary metabolites are important facilitators of plant-microbe interactions in the rhizosphere, contributing to communication, competition, and nutrient acquisition. However, at first glance, the rhizosphere seems full of metabolites with overlapping functions, and we have a… read more here.
Keywords: ecology; iron acquisition; chemical ecology; plant ... See more keywords
Proteome analysis of virulent Aeromonas hydrophila reveals the upregulation of iron acquisition systems in the presence of a xenosiderophore.
Sign Up to like & getrecommendations! Published in 2020 at "FEMS microbiology letters"
DOI: 10.1093/femsle/fnaa169
Abstract: The Gram-negative bacterium, Aeromonas hydrophila, has been responsible for extensive losses in the catfish industry for over a decade. Due to this impact, there are ongoing efforts to understand the basic mechanisms that contribute to… read more here.
Keywords: iron acquisition; iron; proteome analysis; dfo ... See more keywords
CSIG-16. SEXUAL DIMPORHISM IN IRON ACQUISITION IN GLIOBLASTOMA
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.128
Abstract: Glioblastoma (GBM) is the most aggressive brain cancer. Sex differences in incidence and clinical outcomes have been reported, however, our knowledge of contributing mechanisms is limited. Iron acquisition is key to robust tumor growth. Upregulation… read more here.
Keywords: glioblastoma; male female; iron acquisition; iron ... See more keywords
Multi-scale mechanistic modelling of the host defence in invasive aspergillosis reveals leucocyte activation and iron acquisition as drivers of infection outcome
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2021.0806
Abstract: Aspergillus species are ubiquitous environmental moulds, with spores inhaled daily by most humans. Immunocompromised hosts can develop an invasive infection resulting in high mortality. There is, therefore, a pressing need for host-centric therapeutics for this… read more here.
Keywords: multi scale; iron acquisition; leucocyte activation; growth ... See more keywords
Iron Acquisition Mechanisms and Their Role in the Virulence of Acinetobacter baumannii
Sign Up to like & getrecommendations! Published in 2022 at "Infection and Immunity"
DOI: 10.1128/iai.00223-22
Abstract: Iron is an essential element for survival of most organisms. One mechanism of host defense is to tightly chelate iron to several proteins to limit its extracellular availability. ABSTRACT Iron is an essential element for… read more here.
Keywords: iron acquisition; iron; acinetobacter baumannii; virulence ... See more keywords
Regulation of High-Affinity Iron Acquisition, Including Acquisition Mediated by the Iron Permease FtrA, Is Coordinated by AtrR, SrbA, and SreA in Aspergillus fumigatus
Sign Up to like & getrecommendations! Published in 2023 at "mBio"
DOI: 10.1128/mbio.00757-23
Abstract: Aspergillus fumigatus is the most common filamentous fungal pathogen infecting humans. Iron acquisition via siderophores has previously been shown to be essential for virulence of this mold species. ABSTRACT Iron acquisition is crucial for virulence… read more here.
Keywords: iron acquisition; iron; aspergillus fumigatus; regulation ... See more keywords