Design, synthesis and biological evaluation of potential anti-AD hybrids with monoamine oxidase B inhibitory and iron-chelating effects.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104564
Abstract: A series of active hybrids combining 3-hydroxypyridin-4(1H)-one and coumarin pharmacophores were designed and synthesized as potential agents for the treatment of Alzheimer's disease (AD). All the compounds exhibited excellent iron-chelating activities (pFe3+ = 14.8-19.2) and… read more here.
Keywords: iron chelating; potential anti; monoamine oxidase; inhibitory ... See more keywords
Food protein-derived iron-chelating peptides: The binding mode and promotive effects of iron bioavailability.
Sign Up to like & getrecommendations! Published in 2020 at "Food research international"
DOI: 10.1016/j.foodres.2020.108976
Abstract: Iron is known as an essential nutrient in the human body. Insufficient iron uptake is easy to result in iron deficiency anemia, which is a public health problem in both developing and developed countries. Iron,… read more here.
Keywords: iron chelating; bioavailability; chelating peptides; binding mode ... See more keywords
Chromone-based monoamine oxidase B inhibitor with potential iron-chelating activity for the treatment of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2134358
Abstract: Abstract Based on the multitarget-directed ligands (MTDLs) strategy, a series of chromone-hydroxypyridinone hybrids were designed, synthesised, and evaluated as potential multimodal anti-AD ligands. Prospective iron-chelating effects and favourable monoamine oxidase B (MAO-B) inhibitory activities were… read more here.
Keywords: chromone; iron; iron chelating; activity ... See more keywords
An iron-chelating sulfonamide identified from Drosophila-based screening for antipathogenic discovery
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2069325
Abstract: ABSTRACT We exploited bacterial infection assays using the fruit fly Drosophila melanogaster to identify anti-infective compounds that abrogate the pathological consequences in the infected hosts. Here, we demonstrated that a pyridine-3-N-sulfonylpiperidine derivative (4a) protects Drosophila… read more here.
Keywords: chelating sulfonamide; drosophila based; iron; iron chelating ... See more keywords
Iron chelating properties of Eltrombopag: Investigating its role in thalassemia-induced osteoporosis
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DOI: 10.1371/journal.pone.0208102
Abstract: Chronic blood transfusions are responsible to cause iron overload, which leads to several complications to end organs and osteoporosis. Iron chelation is needed to remove iron excess and to contain bone-mass loss. Deferasirox is the… read more here.
Keywords: iron chelating; osteoporosis iron; eltrombopag investigating; iron ... See more keywords
Implication of Dietary Iron-Chelating Bioactive Compounds in Molecular Mechanisms of Oxidative Stress-Induced Cell Ageing
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DOI: 10.3390/antiox10030491
Abstract: One of the prevailing perceptions regarding the ageing of cells and organisms is the intracellular gradual accumulation of oxidatively damaged macromolecules, leading to the decline of cell and organ function (free radical theory of ageing).… read more here.
Keywords: dietary iron; iron chelating; chelating bioactive; iron ... See more keywords