Conservative Iron Chelation for Neuroferritinopathy
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.29145
Abstract: Neuroferritinopathy is a rare inherited neurodegenerative disease with brain iron accumulation characterized by brain iron overload resulting in progressive movement disorders. No treatment is currently available. read more here.
Keywords: iron; conservative iron; chelation neuroferritinopathy; iron chelation ... See more keywords
Do Recent Randomized Trial Results Influence which Patients with Myelodysplastic Syndromes Receive Iron Chelation?
Sign Up to like & getrecommendations! Published in 2020 at "Hematology/oncology clinics of North America"
DOI: 10.1016/j.hoc.2019.10.006
Abstract: Iron overload (IOL) in patients with myelodysplastic syndromes (MDS) is mainly attributable to chronic transfusion therapy. The importance of iron chelation therapy (ICT) in MDS has been a matter of debate. The Telesto study, the… read more here.
Keywords: myelodysplastic syndromes; trial; patients myelodysplastic; iron chelation ... See more keywords
Selective sensitivity of the gut microbiome to iron chelators in polybacterial abdominal sepsis.
Sign Up to like & getrecommendations! Published in 2018 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2018.08.018
Abstract: Iron chelation has been proposed as a potential therapy for polybacterial abdominal sepsis. Treatment with iron chelation is known to be able to attenuate bacterial growth. It is hypothesized that the different types of bacteria… read more here.
Keywords: sepsis; iron chelation; polybacterial abdominal; sensitivity ... See more keywords
Innovative Therapies for Neuroblastoma: The Surprisingly Potent Role of Iron Chelation in Up-Regulating Metastasis and Tumor Suppressors and Down-Regulating the Key Oncogene, N-myc.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105889
Abstract: Iron is an indispensable requirement for essential biological processes in cancer cells. Due to the greater proliferation of neoplastic cells, their demand for iron is considerably higher relative to normal cells, making them highly susceptible… read more here.
Keywords: oncogene myc; iron chelation; cancer; iron ... See more keywords
Adherence to Iron Chelation Therapy among Adults with Thalassemia: A Systematic Review
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DOI: 10.1080/03630269.2022.2072320
Abstract: Abstract Iron chelation therapy (ICT) is essential to prevent complications of iron overload in patients with transfusion-dependent thalassemia. However, the role that adherence to ICT plays in health-related outcomes is less well known. Our objectives… read more here.
Keywords: chelation therapy; ict adherence; adherence; iron chelation ... See more keywords
Iron chelation promotes mitophagy through SENP3-mediated deSUMOylation of FIS1
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DOI: 10.1080/15548627.2022.2046898
Abstract: ABSTRACT The selective clearance of mitochondria by mitophagy is an important quality control mechanism for maintaining mitochondrial and cellular health. Iron chelation, for example by the compound deferiprone (DFP), leads to a specific form of… read more here.
Keywords: senp3; fis1; dfp; iron chelation ... See more keywords
From iron chelation to overload as a therapeutic strategy to induce ferroptosis in hematologic malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Hematology"
DOI: 10.1080/16078454.2022.2132362
Abstract: ABSTRACT Objectives Ferroptosis is an iron-dependent, non-apoptotic mode of cell death characterized by excessive accumulation of reactive oxygen species (ROS). It plays an important role in the occurrence, development and treatment of various cancers, but… read more here.
Keywords: hematologic malignancies; iron chelation; ferroptosis hematologic; ferroptosis ... See more keywords
The impact of iron chelation therapy on patients with lower/intermediate IPSS MDS and the prognostic role of elevated serum ferritin in patients with MDS and AML
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DOI: 10.1097/md.0000000000017406
Abstract: Supplemental Digital Content is available in the text read more here.
Keywords: therapy patients; chelation therapy; lower intermediate; iron chelation ... See more keywords
Could haemochromatosis (HFE) gene mutations affect response to iron chelation in myelodysplastic syndrome? – Response to Lucijanic and Kusec
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Haematology"
DOI: 10.1111/bjh.15938
Abstract: We appreciate the comments by Lucijanic and Kusec on our article “Mutational profile and haematological response to iron chelation in myelodysplastic syndromes (MDS)” (Fabiani et al, 2019). Following their suggestions, we further investigated the mechanisms… read more here.
Keywords: response; iron chelation; h63d; hfe ... See more keywords
Less iron improves MDS haematopoiesis
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Haematology"
DOI: 10.1111/bjh.16012
Abstract: It has been well known for more than a decade, that iron overload adversely affects the prognosis of patients with lower-risk myelodysplastic syndromes (MDS) (Malcovati et al, 2005). Iron overload may be transfusion-related as well… read more here.
Keywords: haematopoiesis; treatment; iron chelation; iron overload ... See more keywords
Clinical view versus guideline adherence in ferritin monitoring and initiating iron chelation therapy in patients with myelodysplastic syndromes
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Haematology"
DOI: 10.1111/ejh.13865
Abstract: In patients with myelodysplastic syndromes (MDS) with >20 transfusions and ferritin levels >1000 μg/L, international guidelines recommend iron chelation therapy (ICT). The study's objective was to determine guideline adherence and the intensity of ferritin monitoring in… read more here.
Keywords: ferritin; iron chelation; myelodysplastic syndromes; guideline adherence ... See more keywords