Lactoferrin, a potential iron-chelator as an adjunct treatment for mucormycosis - A comprehensive review.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.07.156
Abstract: Mucormycosis is a deadly infection which is caused by fungi of the order Mucorales including species belonging to the genus Rhizopus, Mucor, Mycocladus, Rhizomucor, Cunninghamella, and Apophysomyces. Despite antifungal therapy and surgical procedures, the mortality… read more here.
Keywords: iron chelator; mucormycosis; review; iron ... See more keywords
Polyglycerol based Macromolecular Iron Chelator Adjuvants for Antibiotics to Treat Drug Resistant Bacteria.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c06501
Abstract: Iron is an essential micronutrient for life. Its redox activity is a key component in a plethora of vital enzymatic reactions that take place in processes such as drug metabolism, DNA synthesis, steroid synthesis, gene… read more here.
Keywords: iron chelator; resistant bacteria; macromolecular iron; iron ... See more keywords
Tuning the Solid- and Solution-State Fluorescence of the Iron-Chelator Deferasirox.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c01155
Abstract: Deferasirox, an FDA-approved iron chelator, has gained increasing attention for use in anticancer and antimicrobial applications. Recent efforts by our group led to the identification of this core as an easy-to-visualize aggregation-induced emission platform, or… read more here.
Keywords: iron; emission; deferasirox; iron chelator ... See more keywords
Unique Properties Associated with the Brain Penetrant Iron Chelator HBED Reveal Remarkable Beneficial Effects after Brain Trauma.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of neurotrauma"
DOI: 10.1089/neu.2017.5617
Abstract: Iron is postulated to contribute to secondary injury after brain trauma through various pathways including oxidative stress and inflammation. Therefore, one goal is to limit iron toxicity by either directly limiting iron activity, or limiting… read more here.
Keywords: iron chelator; brain; brain trauma; iron ... See more keywords
Effect of the oral iron chelator deferiprone in diabetic nephropathy rats
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Diabetes"
DOI: 10.1111/1753-0407.12420
Abstract: The aim of the present study was to investigate the effects of the iron chelator deferiprone in diabetic nephropathy (DN) rats and the mechanisms involved. read more here.
Keywords: iron chelator; chelator deferiprone; nephropathy rats; deferiprone diabetic ... See more keywords
Safety and efficacy of a novel iron chelator (HBED; (N,N′‐Di(2‐hydroxybenzyl)ethylenediamine‐N,N′‐diacetic acid)) in equine (Equus caballus) as a model for black rhinoceros (Diceros bicornis)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Animal Physiology and Animal Nutrition"
DOI: 10.1111/jpn.13745
Abstract: Abstract While iron overload disorder (IOD) and related disease states are not considered a common occurrence in domestic equids, these issues appear prevalent in black rhinoceroses under human care. In addressing IOD in black rhinos,… read more here.
Keywords: iron; diacetic acid; safety efficacy; iron chelator ... See more keywords
Abstract 1155: Stemness control by iron chelator is a novel therapeutic strategy for esophageal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs18-1155
Abstract: Background:Esophageal cancer has a poor prognosis and high mortality rate because of recurrence and chemo-resistance. Cancer stem cells (CSCs) have been proposed to be responsible for tumor initiation, drug resistance, and recurrence. Although CSCs are… read more here.
Keywords: stemness; iron chelator; esophageal cancer; cancer ... See more keywords
Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14133225
Abstract: Simple Summary MYC proteins are essential regulators which could affect more than 15% of all genes through an interaction with other transcription factors. High-risk neuroblastoma associated with treatment failure is characterized by amplification of the… read more here.
Keywords: chelator vlx600; vlx600; vlx600 inhibits; neuroblastoma ... See more keywords
Improvement of Left Ventricular Graft Function Using an Iron-Chelator-Supplemented Bretschneider Solution in a Canine Model of Orthotopic Heart Transplantation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137453
Abstract: Demand for organs is increasing while the number of donors remains constant. Nevertheless, not all organs are utilized due to the limited time window for heart transplantation (HTX). Therefore, we aimed to evaluate whether an… read more here.
Keywords: bretschneider solution; iron; chelator supplemented; iron chelator ... See more keywords
Anti-Inflammatory Effects of the Iron Chelator, DIBI, in Experimental Acute Lung Injury
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27134036
Abstract: Iron plays a critical role in the immune response to inflammation and infection due to its role in the catalysis of reactive oxygen species (ROS) through the Haber-Weiss and Fenton reactions. However, ROS overproduction can… read more here.
Keywords: lung; injury; chelator dibi; iron chelator ... See more keywords