Hydroxypyridinone-Based Iron Chelators with Broad-Ranging Biological Activities.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01480
Abstract: Iron plays an essential role in all living cells because of its unique chemical properties. It is also the most abundant trace element in mammals. However, when iron is present in excess or inappropriately located,… read more here.
Keywords: iron chelators; chelators broad; based iron; broad ranging ... See more keywords
The mono(catecholamine) derivatives as iron chelators: synthesis, solution thermodynamic stability and antioxidant properties research
Sign Up to like & getrecommendations! Published in 2018 at "Royal Society Open Science"
DOI: 10.1098/rsos.171492
Abstract: There is a growing interest in the development of new iron chelators as novel promising therapeutic strategies for neurodegenerative disorders. In this article, a series of mono(catecholamine) derivatives, 2,3-bis(hydroxy)-N-(hydroxyacyl)benzamide, containing a pendant hydroxy, have been… read more here.
Keywords: iron chelators; antioxidant properties; catecholamine derivatives; thermodynamic stability ... See more keywords
Novel multifunctional iron chelators of the aroyl nicotinoyl hydrazone class that markedly enhance cellular NAD+/NADH ratios
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14963
Abstract: Alzheimer's disease (AD) is a multifactorial condition leading to cognitive decline and represents a major global health challenge in ageing populations. The lack of effective AD therapeutics led us to develop multifunctional nicotinoyl hydrazones to… read more here.
Keywords: iron chelators; chelators aroyl; novel multifunctional; aroyl nicotinoyl ... See more keywords
Polymeric iron chelators for enhancing 5‐aminolevulinic acid‐induced photodynamic therapy
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15637
Abstract: 5‐Aminolevulinic acid (5‐ALA) is an amino acid that can be metabolized into a photosensitizer, protoporphyrin IX (PpIX) selectively in a tumor cell, permitting minimally invasive photodynamic diagnosis/therapy. However, some malignant tumor cells have excess intracellular… read more here.
Keywords: iron chelators; polymeric iron; aminolevulinic acid; iron ... See more keywords
Synthesis and antiproliferative evaluation of some iron chelators as polyamine transporter targeting agents
Sign Up to like & getrecommendations! Published in 2019 at "Canadian Journal of Chemistry"
DOI: 10.1139/cjc-2019-0036
Abstract: A series of kojic acid derivatives based on monoamines, diamines, and triamines have been synthesized in good yield and purity. A spermidine (spd) rescue experiment was applied against MCF-7 cells to evaluate the polyamine transporter… read more here.
Keywords: antiproliferative evaluation; transporter; polyamine transporter; synthesis antiproliferative ... See more keywords
A Promising New Anti-Cancer Strategy: Iron Chelators Targeting CSCs.
Sign Up to like & getrecommendations! Published in 2020 at "Acta medica Okayama"
DOI: 10.18926/amo/57946
Abstract: Iron is a trace but vital element in the human body and is necessary for a multitude of crucial processes in life. However, iron overload is known to induce carcinogenesis via oxidative stress. Cancer cells… read more here.
Keywords: anti cancer; cscs; strategy; cancer ... See more keywords
Cardioprotective Potential of Iron Chelators and Prochelators.
Sign Up to like & getrecommendations! Published in 2019 at "Current medicinal chemistry"
DOI: 10.2174/0929867324666170920155439
Abstract: Heart is a particularly sensitive organ to iron overload and cardiomyopathy due to the excessive cardiac iron deposition causes most deaths in disorders such as beta-thalassemia major. Free or loosely bound iron ions readily cycle… read more here.
Keywords: iron chelators; chelators prochelators; chemistry; iron ... See more keywords
Highly Metastatic Subpopulation of TNBC Cells Has Limited Iron Metabolism and Is a Target of Iron Chelators
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15020468
Abstract: Simple Summary Excess iron is known to be a risk factor of carcinogenesis. Although iron chelators show anti-cancer effects, they have not been used successfully to treat cancer patients. Triple-negative breast cancer (TNBC) is a… read more here.
Keywords: iron chelators; iron; tnbc; tnbc cells ... See more keywords
Binding of Citrate-Fe3+ to Plastic Culture Dishes, an Artefact Useful as a Simple Technique to Screen for New Iron Chelators
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126657
Abstract: NaCT mediates citrate uptake in the liver cell line HepG2. When these cells were exposed to iron (Fe3+), citrate uptake/binding as monitored by the association of [14C]-citrate with cells increased. However, there was no change… read more here.
Keywords: culture; citrate fe3; iron chelators; iron ... See more keywords
Iron Overload and Breast Cancer: Iron Chelation as a Potential Therapeutic Approach
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12070963
Abstract: Breast cancer has historically been one of the leading causes of death for women worldwide. As of 2020, breast cancer was reported to have overtaken lung cancer as the most common type of cancer globally,… read more here.
Keywords: iron chelators; iron; breast cancer; approach ... See more keywords