Ferrous Iron-Dependent Pharmacology.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2020.11.003
Abstract: The recent emergence of oxidation state selective probes of cellular iron has produced a more nuanced understanding of how cells utilize this crucial nutrient to empower enzyme function, and also how labile ferrous iron contributes… read more here.
Keywords: iron dependent; dependent pharmacology; pharmacology; iron ... See more keywords
Reactivity-Based Probe of the Iron(II)-Dependent Interactome Identifies New Cellular Modulators of Ferroptosis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c06709
Abstract: Ferroptosis is an iron-dependent form of cell death resulting from loss or inhibition of cellular machinery that protects from the accumulation of lipid hydroperoxides. Ferroptosis likely serves a tumor suppressing function in normal cellular homeostasis,… read more here.
Keywords: iron dependent; reactivity based; ferroptosis; iron ... See more keywords
Crucial role of iron in epigenetic rewriting during adipocyte differentiation mediated by JMJD1A and TET2 activity.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad342
Abstract: Iron metabolism is closely associated with the pathogenesis of obesity. However, the mechanism of the iron-dependent regulation of adipocyte differentiation remains unclear. Here, we show that iron is essential for rewriting of epigenetic marks during… read more here.
Keywords: histone; role; iron dependent; differentiation ... See more keywords
During Oxidative Stress the Clp Proteins of Escherichia coli Ensure that Iron Pools Remain Sufficient To Reactivate Oxidized Metalloenzymes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Bacteriology"
DOI: 10.1128/jb.00235-20
Abstract: Hydrogen peroxide mediates the toxicity of phagocytes, lactic acid bacteria, redox-cycling antibiotics, and photochemistry. The underlying mechanisms all involve its reaction with iron atoms, whether in enzymes or on the surface of DNA. Accordingly, when… read more here.
Keywords: clp proteins; dna; reactivate; iron dependent ... See more keywords
Abstract MP121: Deleting the 2-oxoglutarate- and Iron-dependent Prolyl Hydroxylase Ogfod1 Alters Purine Nucleotide Regulation and is Cardioprotective
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.mp121
Abstract: Prolyl hydroxylation is a post-translational modification that regulates protein stability, turnover, and activity. The proteins that catalyze prolyl hydroxylation belong to the 2-oxoglutarate- and iron-dependent oxygenase family of enzymes. A newly-described member of this family… read more here.
Keywords: ogfod1; purine nucleotide; iron dependent; mice ... See more keywords
Proteomic profiling of the monothiol glutaredoxin Grx3 reveals its global role in the regulation of iron dependent processes
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008881
Abstract: Iron is an essential nutrient required as a cofactor for many biological processes. As a fungal commensal-pathogen of humans, Candida albicans encounters a range of bioavailable iron levels in the human host and maintains homeostasis… read more here.
Keywords: iron dependent; grx3; regulatory circuit; regulation iron ... See more keywords
Human IRP1 Translocates to the Nucleus in a Cell-Specific and Iron-Dependent Manner
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810740
Abstract: Iron regulatory protein 1 (IRP1) is a bifunctional protein with mutually exclusive RNA-binding or enzymatic activities that depend on the presence of a 4Fe-4S cluster. While IRP1 is a well-established cytosolic protein, work in a… read more here.
Keywords: irp1; iron; iron dependent; nuclear irp1 ... See more keywords
A bipartite iron-dependent transcriptional regulation of the tryptophan salvage pathway in Chlamydia trachomatis
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.42295
Abstract: During infection, pathogens are starved of essential nutrients such as iron and tryptophan by host immune effectors. Without conserved global stress response regulators, how the obligate intracellular bacterium Chlamydia trachomatis arrives at a physiologically similar… read more here.
Keywords: tryptophan; regulation; chlamydia trachomatis; iron dependent ... See more keywords