Association of Genetic Variant Linked to Hemochromatosis With Brain Magnetic Resonance Imaging Measures of Iron and Movement Disorders.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.2030
Abstract: Importance Hereditary hemochromatosis (HH) is an autosomal recessive genetic disorder that leads to iron overload. Conflicting results from previous research has led some to believe the brain is spared the toxic effects of iron in… read more here.
Keywords: movement disorders; iron deposition; movement; brain magnetic ... See more keywords
Susceptibility-weighted imaging and transcranial Doppler ultrasound in patients with cerebral small vessel disease
Sign Up to like & getrecommendations! Published in 2020 at "Neurological Sciences"
DOI: 10.1007/s10072-020-04414-5
Abstract: Introduction Cerebral small vessel disease (SVD) is a common accompaniment to aging. Magnetic resonance imaging (MRI) features of SVD include lacunar infarcts (LI) and white matter hyperintensity (WMH). Brain iron deposition is also a known… read more here.
Keywords: cerebral small; brain iron; brain; iron deposition ... See more keywords
No evidence of iron deposition in essential tremor: a susceptibility-weighted imaging study
Sign Up to like & getrecommendations! Published in 2021 at "Neurological Sciences"
DOI: 10.1007/s10072-021-05173-7
Abstract: To evaluate the role of iron deposition in subcortical nuclei of patients with essential tremor (ET). Twenty-three patients with ET underwent a standardized 3T-MRI protocol. We specifically assessed iron deposition using susceptibility-weighted angiography (SWAN) images… read more here.
Keywords: deposition; susceptibility weighted; iron deposition; essential tremor ... See more keywords
FTY720 attenuates iron deposition and glial responses in improving delayed lesion and long-term outcomes of collagenase-induced intracerebral hemorrhage
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research"
DOI: 10.1016/j.brainres.2019.04.031
Abstract: Most intracerebral hemorrhage (ICH) survivors have poor long-term outcomes, such as cognitive deficits and depression. Delayed lesions of ICH include neuron loss and white matter injury and the pathology of the lesions involves iron deposition… read more here.
Keywords: iron deposition; term; long term; term outcomes ... See more keywords
Quantitative susceptibility mapping depicts severe myelin deficit and iron deposition in a transgenic model of multiple system atrophy
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113314
Abstract: Despite internationally established diagnostic criteria, multiple system atrophy (MSA) is frequently misdiagnosed, particularly at disease onset. While neuropathological changes such as demyelination and iron deposition are typically detected in MSA, these structural hallmarks were so… read more here.
Keywords: iron deposition; deposition; iron; myelin ... See more keywords
Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism
Sign Up to like & getrecommendations! Published in 2019 at "Heliyon"
DOI: 10.1016/j.heliyon.2019.e01637
Abstract: Hepatic iron deposition is seen in cases of chronic hepatitis and cirrhosis, and is a hallmark of a poorer prognosis. Iron deposition is also found in non-alcoholic steatohepatitis (NASH) patients. We have now developed a… read more here.
Keywords: iron; model; iron deposition; iron overload ... See more keywords
Quantifying iron deposition within the substantia nigra of Parkinson's disease by quantitative susceptibility mapping
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2018.01.008
Abstract: BACKGROUND Iron deposition within the substantia nigra (SN) has been postulated to play a vital role in Parkinson's disease (PD). The aim of this study was to explore the inherent link of PD patients between… read more here.
Keywords: iron deposition; disease; substantia nigra; parkinson disease ... See more keywords
Brain iron deposition in patients with white matter hyperintensities of presumed vascular origin
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2016.09.025
Abstract: I read with great interest the paper of Gattringer et al., who reported that “No evidence for increased brain iron deposition in patients with ischemic white matter disease” and who stated that “white matter hyperintensities… read more here.
Keywords: iron deposition; matter; brain iron; deposition patients ... See more keywords
Estrogen deficiency is associated with brain iron deposition via upregulation of hepcidin expression in aged female mice
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.08.010
Abstract: The total iron level in the brain increases with age, and excess iron is associated with neurodegenerative diseases; however, the mechanism of brain iron deposition is unknown. In peripheral cells, the expression of hepcidin, a… read more here.
Keywords: iron deposition; hepcidin; mice; iron ... See more keywords
Different iron deposition patterns in hemodialysis patients with and without restless legs syndrome: a quantitative susceptibility mapping study.
Sign Up to like & getrecommendations! Published in 2020 at "Sleep medicine"
DOI: 10.1016/j.sleep.2019.12.024
Abstract: OBJECTIVE Brain iron deposition in hemodialysis (HD) patients increases over time. Iron deficiency in gray matter nuclei has been reported to lead to idiopathic restless legs syndrome (RLS) symptoms. Regardless of unpleasant RLS sensations, the… read more here.
Keywords: iron deposition; susceptibility; nrls patients; hemodialysis patients ... See more keywords
Tubular iron deposition and iron handling proteins in human healthy kidney and chronic kidney disease
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27107-8
Abstract: Iron is suggested to play a detrimental role in the progression of chronic kidney disease (CKD). The kidney recycles iron back into the circulation. However, the localization of proteins relevant for physiological tubular iron handling… read more here.
Keywords: kidney; iron deposition; iron handling; iron ... See more keywords