Paying the Iron Price: Liver Iron Homeostasis and Metabolic Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c210039
Abstract: Iron is an essential metal element whose bioavailability is tightly regulated. Under normal conditions, systemic and cellular iron homeostases are synchronized for optimal function, based on the needs of each system. During metabolic dysfunction, this… read more here.
Keywords: iron; iron homeostasis; homeostasis metabolic; metabolic dysfunction ... See more keywords
Comparative transcriptome combined with metabolomic and physiological analyses revealed ROS-mediated redox signaling affecting rice growth and cellular iron homeostasis under varying pH conditions
Sign Up to like & getrecommendations! Published in 2018 at "Plant and Soil"
DOI: 10.1007/s11104-018-3859-3
Abstract: Background and aimsMechanisms by which soil pH affects rice growth await further elucidation.MethodsWe have used a Systems Biology approach to elucidate the nature of the damage caused by extreme pH to plant growth and iron… read more here.
Keywords: iron; iron homeostasis; rice growth; rice ... See more keywords
Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.05.009
Abstract: Iron metabolism is regulated by transcriptional and post-transcriptional mechanisms. The mRNA of the iron-controlling gene, transferrin receptor 1 (TfR1), has long been believed to be negatively regulated by a yet-unidentified endonuclease. Here, we show that… read more here.
Keywords: iron homeostasis; degradation; transferrin receptor; iron ... See more keywords
MC-LR induces dysregulation of iron homeostasis by inhibiting hepcidin expression: A preliminary study.
Sign Up to like & getrecommendations! Published in 2018 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2018.08.077
Abstract: The liver is an important iron storage site and a primary MC-LR target. C57BL/6 and Hfe-/- mice were used to investigate effects and mechanisms of MC-LR on systematic iron homeostasis. Body weight, tissue iron content,… read more here.
Keywords: iron homeostasis; c57bl mice; hfe mice; mice ... See more keywords
Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.10.005
Abstract: Iron is a central micronutrient needed by all living organisms. Competition for iron in the intestinal tract is essential for the maintenance of indigenous microbial populations and for host health. How symbiotic relationships between hosts… read more here.
Keywords: iron homeostasis; microbial metabolite; metabolite signaling; systemic iron ... See more keywords
Glutaredoxins in plant development, abiotic stress response, and iron homeostasis: From model organisms to crops
Sign Up to like & getrecommendations! Published in 2017 at "Environmental and Experimental Botany"
DOI: 10.1016/j.envexpbot.2017.04.007
Abstract: Abstract Plant growth, development, and response to environmental stress require the judicious balance of reactive oxygen species (ROS). Glutaredoxins (GRXs) are a group of oxidoreductases that participate in the control of ROS and are traditionally… read more here.
Keywords: iron homeostasis; plant; response; stress ... See more keywords
Evidence of dysregulated iron homeostasis in newly diagnosed diabetics, but not in pre-diabetics.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of diabetes and its complications"
DOI: 10.1016/j.jdiacomp.2021.107977
Abstract: AIM Diabetes mellitus has been reported to be associated with increased serum levels of ferritin. The basis of this association is unclear. It is also not precisely known whether other iron-related parameters, including hepcidin (the… read more here.
Keywords: iron homeostasis; diabetics pre; newly diagnosed; pre diabetics ... See more keywords
Two ferritin genes (MdFerH and MdFerL) are involved in iron homeostasis, antioxidation and immune defense in housefly Musca domestica.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of insect physiology"
DOI: 10.1016/j.jinsphys.2020.104073
Abstract: Ferritin is a ubiquitous multi-subunit iron storage protein, made up of heavy chain and light chain subunits. In recent years, invertebrate ferritins have emerged as an important, yet largely underappreciated, component of host defense and… read more here.
Keywords: homeostasis; iron homeostasis; musca domestica; chain ... See more keywords
FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.02.011
Abstract: Cellular iron homeostasis is dominated by FBXL5-mediated degradation of iron regulatory protein 2 (IRP2), which is dependent on both iron and oxygen. However, how the physical interaction between FBXL5 and IRP2 is regulated remains elusive.… read more here.
Keywords: fbxl5; oxygen; iron homeostasis; iron ... See more keywords
Metabolomic profiling identifies potential pathways involved in the interaction of iron homeostasis with glucose metabolism
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2016.10.006
Abstract: Objective Elevated serum ferritin has been linked to type 2 diabetes (T2D) and adverse health outcomes in subjects with the Metabolic Syndrome (MetS). As the mechanisms underlying the negative impact of excess iron have so… read more here.
Keywords: homeostasis; iron homeostasis; metabolomic profiling; glucose metabolism ... See more keywords
Quartz disrupts iron homeostasis in alveolar macrophages to impact a pro-inflammatory effect.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.8b00301
Abstract: The biological response of bronchial epithelial cells to particles is associated with a sequestration of cell metal by the particle surface and a subsequent disruption in host iron homeostasis. The macrophage is that cell type… read more here.
Keywords: homeostasis; iron homeostasis; silica; exposure ... See more keywords