Structural and Functional Insights into a Nonheme Iron- and α-Ketoglutarate-Dependent Halogenase That Catalyzes Chlorination of Nucleotide Substrates
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DOI: 10.1128/aem.02497-21
Abstract: Halogenated nucleotides are a group of important antibiotics and are clinically used as antiviral and anticancer drugs. AdeV is the first carrier protein-independent nonheme iron- and α-ketoglutarate (αKG)-dependent halogenase (NHFeHal) that can selectively halogenate nucleotides… read more here.
Keywords: adev; iron ketoglutarate; ketoglutarate dependent; nonheme iron ... See more keywords