RNA oxidation and iron levels in patients with diabetes
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.420
Abstract: Aim: The urinary biomarker for oxidative stress to RNA, 8‐oxo‐7,8‐dihydro‐guanosine (8‐oxoGuo) is associated with mortality in patients with type 2 diabetes. Iron has also been linked to diabetes. In individuals with untreated hereditary iron overload… read more here.
Keywords: oxoguo associated; iron biomarkers; iron levels; iron ... See more keywords
Musculoskeletal complications associated with pathological iron toxicity and its molecular mechanisms.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Society transactions"
DOI: 10.1042/bst20200672
Abstract: Iron is fundamental for several biological functions, but when in excess can lead to the development of toxic events. Some tissues and cells are more susceptible than others, but systemic iron levels can be controlled… read more here.
Keywords: iron toxicity; molecular mechanisms; musculoskeletal complications; iron levels ... See more keywords
Impact of serum iron levels on in-hospital mortality and clinical outcomes in patients with ST segment elevation myocardial infarction undergoing emergency percutaneous coronary intervention: a retrospective analysis
Sign Up to like & getrecommendations! Published in 2024 at "Coronary Artery Disease"
DOI: 10.1097/mca.0000000000001393
Abstract: Background Despite advances in percutaneous coronary intervention (PCI) for ST segment elevation myocardial infarction (STEMI), in-hospital mortality remains a concern, highlighting the need for the identification of additional risk factors such as serum iron levels.… read more here.
Keywords: serum iron; iron; hospital mortality; iron levels ... See more keywords
Brain iron transport
Sign Up to like & getrecommendations! Published in 2019 at "Biological Reviews"
DOI: 10.1111/brv.12521
Abstract: Brain iron is a crucial participant and regulator of normal physiological activity. However, excess iron is involved in the formation of free radicals, and has been associated with oxidative damage to neuronal and other brain… read more here.
Keywords: iron transport; brain iron; iron levels; iron ... See more keywords
The Immune-Specific E3 Ubiquitin Ligase MARCH1 Is Upregulated during Human Cytomegalovirus Infection to Regulate Iron Levels
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01806-21
Abstract: Iron is essential for cells, playing important roles in energy generation, DNA replication, and gene expression. During infection, HCMV alters many cellular processes to aid its replication. ABSTRACT Human cytomegalovirus (HCMV) modulates numerous cellular pathways… read more here.
Keywords: march1; iron; infection; many cellular ... See more keywords
A conserved two-component system senses intracellular iron levels and regulates redox balance in Mycobacterium spp.
Sign Up to like & getrecommendations! Published in 2024 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01106-24
Abstract: ABSTRACT For bacteria, an intricate coordination between sensing and regulating iron levels and managing oxidative stress is required as their levels are tightly interlinked. While various oxidative stress and heme-based redox sensors have been reported… read more here.
Keywords: iron; oxidative stress; iron levels; sensor kinase ... See more keywords
Abstract 2128: Hepcidin Loss Demonstrates Sex Dependent Differences In Aortic Aneurysm Size
Sign Up to like & getrecommendations! Published in 2024 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvb.44.suppl_1.2128
Abstract: Background: Studies suggest circulating iron levels play a role in the pathophysiology of abdominal aortic aneurysms (AAAs). Low iron levels lead to medial degeneration and VSMC dysfunction while elevated iron levels promote oxidative stress. Hepcidin… read more here.
Keywords: mice; size; flx; iron levels ... See more keywords
Abstract 4366548: Ferumoxytol Pharmacokinetics in Cardiac Magnetic Resonance
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4366548
Abstract: Introduction: Cardiac MRI (CMR) provides a non-invasive, radiation sparing assessment of anatomy and hemodynamics and is essential in caring for patients with congenital heart disease (CHD). Ferumoxytol (AMAG Pharmaceuticals) is an intravenously administered iron oxide… read more here.
Keywords: serum iron; iron; iron levels; contrast ... See more keywords
Correlation of Iron Levels with Asthma and Lung Function in Pediatric Patients with Sickle Cell Anemia
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-136661
Abstract: Introduction:Significant morbidity and mortality in patients with sickle cell disease (SCD) is attributed to the pulmonary sequalae of the disease. Patients with SCD often suffer airway hyper-reactivity, acute chest syndrome (ACS), chronic lung disease, pulmonary… read more here.
Keywords: patients sickle; patients scd; iron levels; iron ... See more keywords
Intracellular iron levels alter the protein interactome of PCBP1
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-2911
Abstract: Background: Iron is essential for cellular function. Homeostasis of iron is controlled post-transcriptionally via highly conserved mechanisms. We recently found broad changes in alternative splicing with reduced iron availability, consistent with numerous operant mechanisms of… read more here.
Keywords: iron; l2fc 21h7; iron levels; pcbp1 ... See more keywords
Prospective changes of pancreatic iron in patients with thalassemia major and association with chelation therapy
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2022008805
Abstract: We prospectively evaluated in thalassemia major (TM) patients the changes in pancreatic iron levels assessed by T2* magnetic resonance imaging (MRI), their dependence on total body iron balance, and their association with the different iron… read more here.
Keywords: thalassemia major; pancreatic iron; iron; iron levels ... See more keywords