Glyoxal-induced modification enhances stability of hemoglobin and lowers iron-mediated oxidation reactions of the heme protein: An in vitro study.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.08.180
Abstract: Glyoxal, a reactive α-oxoaldehyde, increases in diabetic condition. It reacts with different proteins to form advanced glycation end products (AGEs) following Maillard-like reaction. Considering the significance of AGE-mediated protein modification by glyoxal, here we have… read more here.
Keywords: glyoxal; iron mediated; heme protein; glyoxal induced ... See more keywords
Regiocontrolled Coupling of Alkynes and Dipolar Reagents: Iron-Mediated [3 + 2] Cycloadditions Revisited
Sign Up to like & getrecommendations! Published in 2021 at "Organometallics"
DOI: 10.1021/acs.organomet.1c00032
Abstract: Cyclopentadienyliron dicarbonyl based allenyliron complexes were prepared, and their formal [3 + 2] cycloaddition with a number of dipolar reagents was investigated as a means of preparing heterocy... read more here.
Keywords: dipolar reagents; coupling alkynes; alkynes dipolar; regiocontrolled coupling ... See more keywords
Stereoselective Synthesis of C,C-Glycosides from exo-Glycals Enabled by Iron-Mediated Hydrogen Atom Transfer.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02496
Abstract: We describe herein a convenient strategy for the construction of C,C-glycoside building blocks via the intermediacy of tertiary pseudoanomeric radicals. Application of an iron-mediated hydrogen atom transfer/Michael-Giese coupling enables the anomeric quaternization of readily available… read more here.
Keywords: iron mediated; atom transfer; hydrogen atom; exo glycals ... See more keywords
Targeting Labile Iron-Mediated Ferroptosis Provides a Potential Therapeutic Strategy for Rhabdomyolysis-Induced Acute Kidney Injury.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00914
Abstract: Acute kidney injury (AKI) is a global health problem that occurs in a variety of clinical settings. Despite some advances in supportive clinical care, no medicinal intervention has been demonstrated to reliably prevent AKI thus… read more here.
Keywords: mediated ferroptosis; acute kidney; iron; iron mediated ... See more keywords
Selective Iron-Mediated C- and O-Addition of Phenolic Nucleophiles to a Cyclohexadiene Scaffold Using Renewable Precursors
Sign Up to like & getrecommendations! Published in 2019 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.9b00127
Abstract: Renewable phenols have been investigated as nucleophiles for the addition to a cationic cyclohexadienyl iron carbonyl scaffold. Benign conditions compatible with solvents such as ethanol and water were developed, and for the first time, selective… read more here.
Keywords: addition; mediated addition; selective iron; addition phenolic ... See more keywords
Iron-mediated site-selective oxidative C–H/C–H cross-coupling of aryl radicals with quinones: synthesis of β-secretase-1 inhibitor B and related arylated quinones
Sign Up to like & getrecommendations! Published in 2019 at "Organic Chemistry Frontiers"
DOI: 10.1039/c9qo00623k
Abstract: Phenoxy radicals were converted intoparasite selectiveC-aryl radicals and coupled with quinones, using an inexpensive FeCl3–K2S2O8system, to obtain several arylated quinones, in good to moderate yields. read more here.
Keywords: aryl radicals; selective oxidative; site selective; arylated quinones ... See more keywords
The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-017-0456-2
Abstract: Elevated iron in the SNpc may play a key role in Parkinson’s disease (PD) neurodegeneration since drug candidates with high iron affinity rescue PD animal models, and one candidate, deferirpone, has shown efficacy recently in… read more here.
Keywords: iron mediated; pbt434; synuclein; parkinson disease ... See more keywords