Intracellular Mutual Promotion of Redox Homeostasis Regulation and Iron Metabolism Disruption for Enduring Chemodynamic Therapy
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DOI: 10.1002/adfm.202010390
Abstract: Intracellular redox homeostasis and the iron metabolism system in tumor cells are closely associated with the limited efficacy of chemodynamic therapy (CDT). Despite extensive attempts, maintaining high levels of intracellular catalysts (free iron) and reactants… read more here.
Keywords: chemodynamic therapy; iron; redox homeostasis; iron metabolism ... See more keywords
The BMP‐SMAD pathway mediates the impaired hepatic iron metabolism associated with the ERFE‐A260S variant
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25613
Abstract: The erythroferrone (ERFE) is the erythroid regulator of hepatic iron metabolism by suppressing the expression of hepcidin. Congenital dyserythropoietic anemia type II (CDAII) is an inherited hyporegenerative anemia due to biallelic mutations in the SEC23B… read more here.
Keywords: hepatic iron; iron metabolism; erfe a260s; a260s variant ... See more keywords
The role of hypoxia and inflammation in the regulation of iron metabolism and erythropoiesis in COVID‐19: The IRONCOVID study
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26679
Abstract: Coronavirus Disease (COVID‐19) can be considered as a human pathological model of inflammation combined with hypoxia. In this setting, both erythropoiesis and iron metabolism appear to be profoundly affected by inflammatory and hypoxic stimuli, which… read more here.
Keywords: iron metabolism; covid; inflammation; regulation ... See more keywords
Promising applications of red cell distribution width in diagnosis and prognosis of diseases with or without disordered iron metabolism.
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DOI: 10.1002/cbin.12029
Abstract: Many indicators, including red cell distribution width (RDW) and iron metabolism, are sensitive to a variety of risk factors, and are associated with the pathological alterations and disease onset. RDW reflects the degree of heterogeneous… read more here.
Keywords: rdw; cell; iron; disordered iron ... See more keywords
Hypobaric hypoxia regulates iron metabolism in rats
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DOI: 10.1002/jcb.28683
Abstract: Intermittent hypobaric hypoxia can produce a protective effect on both the nervous system and non‐nervous system tissues. Intermittent hypobaric hypoxia preconditioning has been shown to protect rats from cardiac ischemia‐reperfusion injury by decreasing cardiac iron… read more here.
Keywords: hypobaric hypoxia; treatment; hypoxia; iron metabolism ... See more keywords
The key roles of organelles and ferroptosis in Alzheimerʼs disease
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DOI: 10.1002/jnr.25033
Abstract: Alzheimerʼs disease (AD), an age‐related neurodegenerative disease, is a striking global health problem. Ferroptosis is a newly discovered form of cell death characterized by iron‐dependent lipid peroxidation products and the accumulation of lethal reactive oxygen… read more here.
Keywords: iron metabolism; organelles ferroptosis; alzheimer disease; disease ... See more keywords
Changes in iron metabolism during prolonged repeated walking exercise in middle-aged men and women
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Applied Physiology"
DOI: 10.1007/s00421-018-3961-5
Abstract: PurposeThe aim of the present study was to assess the effect of prolonged and repeated exercise on iron metabolism in middle-aged adults and to compare differences between sexes.Methods50 male (58.9 ± 9.9 year) and 48 female (50.9 ± 11.2 year) individuals… read more here.
Keywords: iron metabolism; prolonged repeated; middle aged; iron ... See more keywords
Expression of genes associated with inflammation and iron metabolism in 3T3-L1 cells induced with macrophages-conditioned medium, glucose and iron
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DOI: 10.1007/s10534-018-0108-4
Abstract: Obesity is characterized by a chronic inflammatory process, with an increased volume of total adipose tissue, especially visceral, which secretes pro-inflammatory cytokines such as TNF-α and IL-6. Hepcidin (Hpc), a main iron metabolism regulator, is… read more here.
Keywords: conditioned medium; iron metabolism; glucose iron; iron ... See more keywords
Cuprizone Administration Alters the Iron Metabolism in the Mouse Model of Multiple Sclerosis
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DOI: 10.1007/s10571-018-0578-5
Abstract: Cuprizone (CZ) is a widely used copper chelating agent to develop non-autoimmune animal model of multiple sclerosis, characterized by demyelination of the corpus callosum (CC) and other brain regions. The exact mechanisms of CZ action… read more here.
Keywords: iron; model; multiple sclerosis; iron metabolism ... See more keywords
Extracellular α-Synuclein Modulates Iron Metabolism Related Proteins via Endoplasmic Reticulum Stress in MES23.5 Dopaminergic Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03292-3
Abstract: Alpha-synuclein plays a vital role in the pathology of Parkinson's disease (PD). Spreading of α-synuclein in neighboring cells was believed to contribute to progression in PD. How α-synuclein transmission affects adjacent cells is not full… read more here.
Keywords: stress; regulation; synuclein; iron metabolism ... See more keywords
Status of Iron Metabolism 10 Years After Roux-En-Y Gastric Bypass
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DOI: 10.1007/s11695-017-2582-0
Abstract: BackgroundThe aim of this study is to investigate changes in iron metabolism and verify whether biochemical parameters are related to the use of oral iron supplement 10 years after Roux-en-Y gastric bypass.MethodsThis longitudinal retrospective study included… read more here.
Keywords: gastric bypass; iron metabolism; iron supplement; iron ... See more keywords