New Deferric Amine Compounds Efficiently Chelate Excess Iron to Treat Iron Overload Disorders and to Prevent Ferroptosis
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DOI: 10.1002/advs.202202679
Abstract: Excess iron accumulation occurs in organs of patients with certain genetic disorders or after repeated transfusions. No physiological mechanism is available to excrete excess iron and iron overload to promote lipid peroxidation to induce ferroptosis,… read more here.
Keywords: iron overload; deferric amine; iron; new deferric ... See more keywords
Hemolysis and hemolysis‐related complications in females vs. males with sickle cell disease
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DOI: 10.1002/ajh.25258
Abstract: iron overload. We used a reference group of SCD and β-thalassemia patients. Percentage iron overload in our transfused SCD patients was comparable to published data. However, we did also find 2 patients with SCD (1… read more here.
Keywords: rare hha; hemolysis; iron overload; iron ... See more keywords
Iron overload after complement inhibitor treatment of Paroxysmal Nocturnal Hemoglobinuria
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DOI: 10.1002/ajh.26187
Abstract: Paroxysmal nocturnal hemoglobinuria (PNH) is an uncommon bone marrow disorder associated with hemolytic anemia, thrombosis, and cytopenias. Prior to 2007, treatment for PNH was limited and patients with PNH were treated with corticosteroids, anticoagulation for… read more here.
Keywords: treatment; paroxysmal nocturnal; iron overload; nocturnal hemoglobinuria ... See more keywords
Optic neuropathy in iron overload and iron chelation therapy
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DOI: 10.1002/ajh.26511
Abstract: States of systemic iron overaload, such as hereditary hemosiderosis and iron overload secondary to transfusion dependence, are known to be associated with optic neuropathy. 1 – 3 Similarly, several studies have shown the treatment of… read more here.
Keywords: chelation therapy; optic neuropathy; iron overload; iron ... See more keywords
The clinical relevance of detectable plasma iron species in iron overload states and subsequent to intravenous iron‐carbohydrate administration
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DOI: 10.1002/ajh.26819
Abstract: Many disorders of iron homeostasis (e.g., iron overload) are associated with the dynamic kinetic profiles of multiple non‐transferrin bound iron (NTBI) species, chronic exposure to which is associated with deleterious end‐organ effects. Here we discuss… read more here.
Keywords: intravenous iron; iron; iron overload; iron carbohydrate ... See more keywords
Iron overload in patients with myelodysplastic syndromes: An updated overview
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DOI: 10.1002/cncr.31550
Abstract: Myelodysplastic syndromes (MDS) encompass a heterogeneous group of clonal hematopoietic stem cell disorders characterized by a broad clinical spectrum related to ineffective hematopoiesis leading to unilineage or multilineage cytopenias, with a high propensity for transformation… read more here.
Keywords: overload patients; myelodysplastic syndromes; patients mds; iron overload ... See more keywords
Astrocytic expression of ZIP14 (SLC39A14) is part of the inflammatory reaction in chronic neurodegeneration with iron overload
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DOI: 10.1002/glia.23806
Abstract: Neurodegeneration is associated with inflammation and mismanaged iron homeostasis, leading to increased concentration of non‐transferrin‐bound iron (NTBI) in the brain. NTBI can be taken up by cells expressing Zrt‐, Irt‐like protein‐14 (ZIP14), which is regulated… read more here.
Keywords: neurodegeneration; iron overload; expression; zip14 ... See more keywords
Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-induced hepatotoxicity.
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DOI: 10.1002/hep.32270
Abstract: BACKGROUND AND AIMS Iron overload is a frequent finding in the general population. As the major iron storage site, liver is subject to iron toxicity. Farnesoid X receptor (FXR) regulates bile acid metabolism and is… read more here.
Keywords: iron; iron overload; mice; fxr ... See more keywords
Icariin protects against iron overload‐induced bone loss via suppressing oxidative stress
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DOI: 10.1002/jcp.27678
Abstract: Iron overload is common in patients with diseases such as hemoglobinopathies, hereditary hemochromatosis or elderly men and postmenopausal women. This disorder is frequently associated with bone loss and recently has been considered as an independent… read more here.
Keywords: icariin; iron overload; overload induced; bone loss ... See more keywords
Oxidative and glycolytic skeletal muscles deploy protective mechanisms to avoid atrophy under pathophysiological iron overload.
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DOI: 10.1002/jcsm.12897
Abstract: BACKGROUND Iron excess has been proposed as an essential factor in skeletal muscle wasting. Studies have reported correlations between muscle iron accumulation and atrophy, either through ageing or by using experimental models of secondary iron… read more here.
Keywords: iron; muscle; iron overload; skeletal muscle ... See more keywords
Quantification of liver fat in the presence of iron overload
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DOI: 10.1002/jmri.25382
Abstract: To evaluate the accuracy of R2* models (1/T2* = R2*) for chemical shift‐encoded magnetic resonance imaging (CSE‐MRI)‐based proton density fat‐fraction (PDFF) quantification in patients with fatty liver and iron overload, using MR spectroscopy (MRS) as… read more here.
Keywords: quantification liver; iron overload; fat presence; liver fat ... See more keywords