Iron‐Sulfur Peptides Mimicking Ferredoxin for an Efficient Electron Transfer to Hydrogenase
Sign Up to like & getrecommendations! Published in 2024 at "ChemBioChem"
DOI: 10.1002/cbic.202400380
Abstract: In the green alga Chlamydomonas reinhardtii, hydrogenase HydA1 converts protons and electrons to H2 at the H‐cluster, which includes a [4Fe−4S] cluster linked to a [2Fe] cluster. The yield of H2 is limited by the… read more here.
Keywords: electron transfer; transfer; iron sulfur;
Cyanophenylalanine as an Infrared Probe for Iron–Sulfur Cluster Redox State in Multicenter Metalloenzymes
Sign Up to like & getrecommendations! Published in 2025 at "Chembiochem"
DOI: 10.1002/cbic.202500251
Abstract: The noncanonical amino acid, para‐cyanophenylalanine (CNF), when incorporated into metalloproteins, functions as an infrared spectroscopic probe for the redox state of iron‐sulfur clusters, offering a strategy for determining electron occupancy in the electron transport chains… read more here.
Keywords: iron sulfur; redox state; cluster; active site ... See more keywords
Iron‐sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23178
Abstract: Demyelinated brain lesions, a hallmark of autoimmune neuroinflammatory diseases like multiple sclerosis, result from oligodendroglial cell damage. Activated microglia are considered a major source of nitric oxide and subsequent peroxynitrite‐mediated damage of myelin. Here, we… read more here.
Keywords: iron sulfur; glutaredoxin; activated microglia; damage ... See more keywords
Mammalian iron sulfur cluster biogenesis and human diseases
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2597
Abstract: Fe-S cluster biogenesis is a multistep process that involves a complex sequence of catalyzed protein– protein interactions and coupled conformational changes between the components of several dedicated multimeric complexes. Intensive studies of the assembly process… read more here.
Keywords: mammalian iron; cluster biogenesis; biogenesis; sulfur cluster ... See more keywords
Secondary structure analysis of peptides with relevance to iron–sulfur cluster nesting
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.25741
Abstract: Peptides coordinated to iron–sulfur clusters, referred to as maquettes, represent a synthetic strategy for constructing biomimetic models of iron–sulfur metalloproteins. These maquettes have been successfully employed as building blocks of engineered heme‐containing proteins with electron‐transfer… read more here.
Keywords: iron; cluster nesting; secondary structure; iron sulfur ... See more keywords
Assessing Electronic‐Structure Methods for Redox Potentials of an Iron‐Sulfur Cluster
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Quantum Chemistry"
DOI: 10.1002/qua.70068
Abstract: Iron‐sulfur (FeS) clusters play a crucial role in biological redox processes. In this study, we evaluate the accuracy of various electronic‐structure methods for calculating the redox potentials of the synthetic [Fe4S4(SC(CH3)3)4] cluster by comparing them… read more here.
Keywords: structure methods; iron sulfur; redox potentials; cluster ... See more keywords
Enzymatic and Chemical In Vitro Reconstitution of Iron-Sulfur Cluster Proteins.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1605-5_5
Abstract: Iron-sulfur (Fe-S) clusters are key cofactors for proteins involved in essential cellular processes such as DNA replication and repair, ribosome biogenesis, tRNA thio-modification, and co-enzyme synthesis. Fe-S clusters can assemble spontaneously from inorganic compounds, but… read more here.
Keywords: enzymatic chemical; cluster; iron sulfur;
Investigating the role(s) of SufT and the domain of unknown function 59 (DUF59) in the maturation of iron–sulfur proteins
Sign Up to like & getrecommendations! Published in 2017 at "Current Genetics"
DOI: 10.1007/s00294-017-0716-5
Abstract: Comprehending biology at the molecular and systems levels is predicated upon understanding the functions of proteins. Proteins are typically composed of one or more functional moieties termed domains. Members of Bacteria, Eukarya, and Archaea utilize… read more here.
Keywords: function; domain unknown; unknown function; iron sulfur ... See more keywords
Molecular chaperones involved in mitochondrial iron–sulfur protein biogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biological Inorganic Chemistry"
DOI: 10.1007/s00775-017-1504-x
Abstract: Iron–sulfur (FeS) clusters are prosthetic groups critical for the function of many proteins in all domains of life. FeS proteins function in processes ranging from oxidative phosphorylation and cofactor biosyntheses to DNA/RNA metabolism and regulation… read more here.
Keywords: protein; fes cluster; iron sulfur; biogenesis ... See more keywords
Iron–sulfur cluster redox chemistry and dimer dissociation in the outer mitochondrial membrane protein, mitoNEET
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biological Inorganic Chemistry"
DOI: 10.1007/s00775-024-02093-7
Abstract: The outer mitochondrial membrane protein known as mitoNEET was discovered when it was labeled by a photoaffinity derivative of the anti-diabetes medication, pioglitazone. The biological role for mitoNEET and its specific mechanism for achieving this… read more here.
Keywords: chemistry; iron sulfur; protein; membrane ... See more keywords
The indispensable role of mammalian iron sulfur proteins in function and regulation of multiple diverse metabolic pathways
Sign Up to like & getrecommendations! Published in 2019 at "Biometals"
DOI: 10.1007/s10534-019-00191-7
Abstract: AbstractIn recent years, iron sulfur (Fe–S) proteins have been identified as key players in mammalian metabolism, ranging from long-known roles in the respiratory complexes and the citric acid cycle, to more recently recognized roles in… read more here.
Keywords: role mammalian; indispensable role; iron sulfur; metabolic pathways ... See more keywords