Iron‐sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23178
Abstract: Demyelinated brain lesions, a hallmark of autoimmune neuroinflammatory diseases like multiple sclerosis, result from oligodendroglial cell damage. Activated microglia are considered a major source of nitric oxide and subsequent peroxynitrite‐mediated damage of myelin. Here, we… read more here.
Keywords: iron sulfur; glutaredoxin; activated microglia; damage ... See more keywords
Mammalian iron sulfur cluster biogenesis and human diseases
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2597
Abstract: Fe-S cluster biogenesis is a multistep process that involves a complex sequence of catalyzed protein– protein interactions and coupled conformational changes between the components of several dedicated multimeric complexes. Intensive studies of the assembly process… read more here.
Keywords: mammalian iron; cluster biogenesis; biogenesis; sulfur cluster ... See more keywords
Secondary structure analysis of peptides with relevance to iron–sulfur cluster nesting
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.25741
Abstract: Peptides coordinated to iron–sulfur clusters, referred to as maquettes, represent a synthetic strategy for constructing biomimetic models of iron–sulfur metalloproteins. These maquettes have been successfully employed as building blocks of engineered heme‐containing proteins with electron‐transfer… read more here.
Keywords: iron; cluster nesting; secondary structure; iron sulfur ... See more keywords
Enzymatic and Chemical In Vitro Reconstitution of Iron-Sulfur Cluster Proteins.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1605-5_5
Abstract: Iron-sulfur (Fe-S) clusters are key cofactors for proteins involved in essential cellular processes such as DNA replication and repair, ribosome biogenesis, tRNA thio-modification, and co-enzyme synthesis. Fe-S clusters can assemble spontaneously from inorganic compounds, but… read more here.
Keywords: enzymatic chemical; cluster; iron sulfur;
Investigating the role(s) of SufT and the domain of unknown function 59 (DUF59) in the maturation of iron–sulfur proteins
Sign Up to like & getrecommendations! Published in 2017 at "Current Genetics"
DOI: 10.1007/s00294-017-0716-5
Abstract: Comprehending biology at the molecular and systems levels is predicated upon understanding the functions of proteins. Proteins are typically composed of one or more functional moieties termed domains. Members of Bacteria, Eukarya, and Archaea utilize… read more here.
Keywords: function; domain unknown; unknown function; iron sulfur ... See more keywords
Molecular chaperones involved in mitochondrial iron–sulfur protein biogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biological Inorganic Chemistry"
DOI: 10.1007/s00775-017-1504-x
Abstract: Iron–sulfur (FeS) clusters are prosthetic groups critical for the function of many proteins in all domains of life. FeS proteins function in processes ranging from oxidative phosphorylation and cofactor biosyntheses to DNA/RNA metabolism and regulation… read more here.
Keywords: protein; fes cluster; iron sulfur; biogenesis ... See more keywords
The indispensable role of mammalian iron sulfur proteins in function and regulation of multiple diverse metabolic pathways
Sign Up to like & getrecommendations! Published in 2019 at "Biometals"
DOI: 10.1007/s10534-019-00191-7
Abstract: AbstractIn recent years, iron sulfur (Fe–S) proteins have been identified as key players in mammalian metabolism, ranging from long-known roles in the respiratory complexes and the citric acid cycle, to more recently recognized roles in… read more here.
Keywords: role mammalian; indispensable role; iron sulfur; metabolic pathways ... See more keywords
Characterization and uranium bioleaching performance of mixed iron- and sulfur-oxidizers versus iron-oxidizers
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Radioanalytical and Nuclear Chemistry"
DOI: 10.1007/s10967-017-5569-3
Abstract: In order to develop and apply mixed iron- and sulfur-oxidizers in uranium bioleaching, the characteristics of a mixed iron- and sulfur-oxidizing consortium (Consortium ISO) were comparatively investigated versus an iron-oxidizing consortium (Consortium IO). The results… read more here.
Keywords: consortium; iron sulfur; uranium bioleaching; sulfur oxidizers ... See more keywords
Structure and electrochemistry of proteins harboring iron-sulfur clusters of different nuclearities. Part V. Nitrogenases
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DOI: 10.1016/j.ccr.2019.07.001
Abstract: Abstract Nitrogen is a crucial component of DNA, RNA and proteins, or the essential element that allows animals and plants to live and grow. Nevertheless, since most of the nitrogen in the atmosphere is unavailable… read more here.
Keywords: iron sulfur; structure electrochemistry; sulfur clusters; electrochemistry ... See more keywords
Functional analysis of iron-sulfur cluster biogenesis (SUF pathway) from Plasmodium vivax clinical isolates.
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DOI: 10.1016/j.exppara.2019.01.015
Abstract: Iron-sulfur (Fe-S) clusters are critical metallo-cofactors required for cell function. Assembly of these cofactors is a carefully controlled process in cells to avoid toxicity from free iron and sulfide. In Plasmodium, two pathways for these… read more here.
Keywords: iron sulfur; cluster biogenesis; vivax clinical; clinical isolates ... See more keywords
Iron-sulfur [2Fe-2S] nitrosyl complexes as new trend in synthesis of donors of nitric oxide for anti-aging therapy
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.073
Abstract: Aging is associated with dysfunctions in vascular smooth muscle cells, neurotransmission, renal and immune systems, to name just a few, many of which stems from decline in reliability of the regulatory functions of nitric oxide… read more here.
Keywords: medicine; nitrosyl complexes; iron sulfur; nitrosyl ... See more keywords