Prophylactic administration of podophyllotoxin and rutin combination assists the revival of radiation-induced hematopoietic suppression in lethally irradiated mice.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.02.085
Abstract: Hematopoietic syndrome contributes to mortality after exposure to high doses of low LET radiation. In this context, we have earlier demonstrated the potential of G-003 M (a combination of podophyllotoxin and rutin) in alleviating radiation-induced bone… read more here.
Keywords: combination; lethally irradiated; radiation induced; irradiated mice ... See more keywords
Screening of biomarkers for liver adenoma in low-dose-rate γ-ray-irradiated mice
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2018.1439193
Abstract: Abstract Purpose: Chronic low-dose-rate (20 mGy/day) γ-irradiation increases the incidence of hepatocellular adenomas (HCA) in female B6C3F1 mice. The purpose of this study is to identify potential serum biomarkers for these HCAs by a new… read more here.
Keywords: biomarkers liver; low dose; irradiated mice; screening biomarkers ... See more keywords
Fucoxanthin alters the apelin-13/APJ pathway in certain organs of γ-irradiated mice
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Radiation Research"
DOI: 10.1093/jrr/rraa141
Abstract: Abstract Apelin-13 and APJ are implicated in different key physiological processes. This work aims at exploring the radioprotective effect of fucoxanthin (FX) on γ-radiation (RAD)-induced changes in the apelin-13/APJ pathway, which causes damage in the… read more here.
Keywords: apj pathway; apelin apj; fucoxanthin alters; irradiated mice ... See more keywords
Total body irradiation induced mouse small intestine senescence as a late effect
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Radiation Research"
DOI: 10.1093/jrr/rrz026
Abstract: Abstract Radiation can induce senescence in many organs and tissues; however, it is still unclear how radiation stimulates senescence in mouse small intestine. In this study, we use the bone marrow transplantation mouse model to… read more here.
Keywords: irradiated mice; senescence; total body; small intestine ... See more keywords
Micro-RNA and Proteomic Profiles of Plasma-Derived Exosomes from Irradiated Mice Reveal Molecular Changes Preventing Apoptosis in Neonatal Cerebellum
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23042169
Abstract: Cell communication via exosomes is capable of influencing cell fate in stress situations such as exposure to ionizing radiation. In vitro and in vivo studies have shown that exosomes might play a role in out-of-target… read more here.
Keywords: neonatal cerebellum; exosomes irradiated; wbi pbi; radiation ... See more keywords
UHPLC/MS-Based Serum Metabolomics Reveals the Mechanism of Radiation-Induced Thrombocytopenia in Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147978
Abstract: Radiation-induced thrombocytopenia is a common and life-threatening side effect of ionizing radiation (IR) therapy. However, the underlying pathological mechanisms remain unclear. In the present study, irradiation was demonstrated to significantly reduce platelet levels, inhibit megakaryocyte… read more here.
Keywords: metabolism; irradiated mice; induced thrombocytopenia; radiation ... See more keywords
An Analysis of the Serum Metabolomic Profile for the Radiomitigative Effect of the Thrombopoietin Receptor Agonist Romiplostim in Lethally Whole-Body-Irradiated Mice
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DOI: 10.3390/metabo12020161
Abstract: The thrombopoietin receptor agonist romiplostim (RP) was recently approved by the US Food and Drug Administration for improving survival in patients acutely exposed to myelosuppressive doses of radiation. Our previous studies with mice have shown… read more here.
Keywords: radiomitigative effect; thrombopoietin receptor; agonist romiplostim; irradiated mice ... See more keywords