The role of reversible and irreversible covalent chemistry in targeted protein degradation.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2021.03.005
Abstract: Proteolysis-targeting chimeras (PROTACs) that degrade disease-causing proteins by hijacking the endogenous ubiquitin-proteasome system have emerged as an exciting and transformative technology in both chemical biology and drug discovery. Currently, the majority of PROTACs use reversible… read more here.
Keywords: chemistry; biology; irreversible covalent; role reversible ... See more keywords