Elucidating molecular mechanisms and therapeutic synergy: irreversible HER2-TKI plus T-Dxd for enhanced anti-HER2 treatment of gastric cancer
Sign Up to like & getrecommendations! Published in 2024 at "Gastric Cancer"
DOI: 10.1007/s10120-024-01478-6
Abstract: HER2-targeted therapies have improved the outcomes of HER2-positive gastric cancer (GC), yet resistance remains a challenge. We sought to explore the effects of reversible and irreversible HER2 tyrosine kinase inhibitors (TKIs) alone or in combination… read more here.
Keywords: dxd; her2 tkis; gastric cancer; irreversible her2 ... See more keywords
Abstract 4034: A potent and highly selective irreversible HER2 inhibitor for treating HER2-driven cancers
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4034
Abstract: HER2 amplification and mutations occur frequently in multiple human cancers, including breast, ovarian, gastric and lung cancers. Despite HER2 being one of the earliest oncogenic drivers discovered, HER2 inhibitors have had limited clinical success compared… read more here.
Keywords: ent; her2; inhibitor; driven cancers ... See more keywords