An LC–MS/MS Assay of Irsenontrine, a Novel Phosphodiesterase‑9 Inhibitor, in Human Plasma, Urine and Cerebrospinal Fluid for Application to Clinical Pharmacokinetic Studies
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DOI: 10.1021/acsomega.5c05431
Abstract: Irsenontrine is a novel phosphodiesterase-9 inhibitor that has been developed for the treatment of cognitive dysfunction. To assess the pharmacokinetics, excretion, and distribution of the drug in humans, comprehensive assays for irsenontrine were developed using… read more here.
Keywords: irsenontrine novel; cerebrospinal fluid; phosphodiesterase inhibitor; urine cerebrospinal ... See more keywords