Actin Filaments Couple the Protrusive Tips to the Nucleus through the I‐BAR Domain Protein IRSp53 during the Migration of Cells on 1D Fibers
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DOI: 10.1002/advs.202207368
Abstract: The cell migration cycle, well‐established in 2D, proceeds with forming new protrusive structures at the cell membrane and subsequent redistribution of contractile machinery. Three‐dimensional (3D) environments are complex and composed of 1D fibers, and 1D… read more here.
Keywords: cell; irsp53; actin filaments; filaments couple ... See more keywords
Activated I-BAR IRSp53 clustering controls the formation of VASP-actin–based membrane protrusions
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DOI: 10.1126/sciadv.abp8677
Abstract: Filopodia are actin-rich membrane protrusions essential for cell morphogenesis, motility, and cancer invasion. How cells control filopodia initiation on the plasma membrane remains elusive. We performed experiments in cellulo, in vitro and in silico to… read more here.
Keywords: membrane protrusions; irsp53; filopodia initiation; vasp ... See more keywords
Insulin Receptor Substrate p53 Ameliorates High-Glucose-Induced Activation of NF-κB and Impaired Mobility of HUVECs
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DOI: 10.1155/2021/3210586
Abstract: Diabetes-related macrovascular and microvascular complications lead to poor prognosis. Insulin receptor substrate p53 (IRSp53) is known to act as a substrate for the insulin receptor tyrosine kinase, but its role in endothelial dysfunction remains unclear.… read more here.
Keywords: mobility; insulin receptor; huvecs; activation ... See more keywords
Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53
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DOI: 10.7554/elife.67321
Abstract: During HIV-1 particle formation, the requisite plasma membrane curvature is thought to be solely driven by the retroviral Gag protein. Here, we reveal that the cellular I-BAR protein IRSp53 is required for the progression of… read more here.
Keywords: irsp53; hiv particles; membrane curvature; membrane ... See more keywords